Publications by authors named "Brian D Klein"

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Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3-WG1A General Pharmacology Working Group of the ILAE/AES Joint Translational Task Force.
Lisa Coles, Patrick A Forcelli, Karine Leclercq, Anna-Maria Katsarou, Brian D Klein

Epilepsia Open· August 2025

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A companion to the preclinical common data elements for rigor, reproducibility and transparency in basic and translational epilepsy research. A report of the TASK3-WG1A: Pharmacology Working Group of the ILAE/AES Joint Translational Task Force.
Brian D Klein, Lauren Harte-Hargrove, Wenzhu Mowrey, Aristea S Galanopoulou, Cameron S Metcalf

Epilepsia Open· August 2025

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Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
Cameron S Metcalf, Brian D Klein, Misty D Smith, Marc Ceusters, Hilde Lavreysen

Epilepsia· March 2018

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Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.
Cameron S Metcalf, Misty D Smith, Brian D Klein, Daniel R McDougle, Liuyin Zhang

Neurochem Res· July 2017

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The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP).
John H Kehne, Brian D Klein, Shamsi Raeissi, Shalini Sharma

Neurochem Res· July 2017

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Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).
Brian D Klein, Catherine A Jacobson, Cameron S Metcalf, Misty D Smith, Karen S Wilcox

Neurochem Res· July 2017

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Efficacy of mGlu -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.
Cameron S Metcalf, Brian D Klein, Misty D Smith, Tim Pruess, Marc Ceusters

Epilepsia· March 2017

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Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.
Cameron S Metcalf, Brian D Klein, Daniel R McDougle, Liuyin Zhang, Dan Kaufmann

Epilepsia· February 2017

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Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models.
Cameron S Metcalf, Brian D Klein, Daniel R McDougle, Liuyin Zhang, Misty D Smith

J Pharmacol Exp Ther· January 2015

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Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.
Marine Jequier Gygax, Brian D Klein, H Steve White, Mimi Kim, Aristea S Galanopoulou

Epilepsy Res· January 2014

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Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
David F McComsey, Virginia L Smith-Swintosky, Michael H Parker, Douglas E Brenneman, Ewa Malatynska, Brian D Klein

J Med Chem· November 2013

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Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.
Liuyin Zhang, Brian D Klein, Cameron S Metcalf, Misty D Smith, Daniel R McDougle

Mol Pharm· February 2013

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Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling.
Brad R Green, Brian D Klein, Hee-Kyoung Lee, Misty D Smith, H Steve White

Bioorg Med Chem· January 2013

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Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models.
H Steve White, Erika A Scholl, Brian D Klein, Sean P Flynn, Timothy H Pruess

Neurotherapeutics· April 2009

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Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity.
Grzegorz Bulaj, Min-Min Zhang, Brad R Green, Brian Fiedler, Richard T Layer, Brian D Klein

Biochemistry· June 2006

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Auditory deficits associated with the frings mgr1 (mass1) mutation in mice.
Brian D Klein, Ying-Hui Fu, Louis J Ptacek, H Steve White

Dev Neurosci· October 2005

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c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse.
Brian D Klein, Ying-Hui Fu, Louis J Ptacek, H Steve White

Epilepsy Res· November 2004

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Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.
Nina Isoherranen, H Steve White, Brian D Klein, Michael Roeder, José H Woodhead

Pharm Res· August 2003

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