Publications by authors named "Marc Ceusters"

Claim this Profile
P
P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.
Mariana Alves, Laura de Diego-Garcia, Gloria Vegliante, Oscar Moreno, Beatriz Gil, Marc Ceusters

Theranostics· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
Omar Mamad, Mona Heiland, Andreas U Lindner, Thomas D M Hill, Ronan M Ronroy, Marc Ceusters

Front Pharmacol· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice.
Jonathon Smith, Aida Menéndez Méndez, Mariana Alves, Alberto Parras, Giorgia Conte, Marc Ceusters

Br J Pharmacol· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.
Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M A van Gerven, Marc Ceusters

Transl Psychiatry· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Increased uptake of the P2X7 receptor radiotracer F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice.
James Morgan, Oscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Marc Ceusters

Epilepsia· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time.
Gallen Triana-Baltzer, Maarten Timmers, Peter De Boer, Manja Schoene, Maura Furey, Marc Ceusters

Compr Psychoneuroendocrinol· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1 female mice.
Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters

Dis Model Mech· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders.
Anindya Bhattacharya, Marc Ceusters

Neuropsychopharmacology· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446.
Michel Koole, Mark E Schmidt, Anja Hijzen, Paulien Ravenstijn, Corinne Vandermeulen, Marc Ceusters

J Nucl Med· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants.
Maarten Timmers, Paulien Ravenstijn, Liwen Xi, Gallen Triana-Baltzer, Maura Furey, Marc Ceusters

J Psychopharmacol· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
Cameron S Metcalf, Brian D Klein, Misty D Smith, Marc Ceusters, Hilde Lavreysen

Epilepsia· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
4
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aluisio, Jose Ignacio Andres, Marc Ceusters

J Med Chem· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficacy of mGlu -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.
Cameron S Metcalf, Brian D Klein, Misty D Smith, Tim Pruess, Marc Ceusters

Epilepsia· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
Jose María Cid, Gary Tresadern, Juan Antonio Vega, Ana Isabel de Lucas, Alcira Del Cerro, Marc Ceusters

J Med Chem· September 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy.
Halima Amhaoul, Idrish Ali, Marco Mola, Annemie Van Eetveldt, Krystyna Szewczyk, Marc Ceusters

Neuropharmacology· June 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression.
Justine M Kent, Ella Daly, Iva Kezic, Rosanne Lane, Pilar Lim, Marc Ceusters

Prog Neuropsychopharmacol Biol Psychiatry· June 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
Cecilia Betti, Joanna Starnowska, Joanna Mika, Jolanta Dyniewicz, Lukasz Frankiewicz, Marc Ceusters

ACS Med Chem Lett· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
Brian Lord, Leah Aluisio, James R Shoblock, Robert A Neff, Elena I Varlinskaya, Marc Ceusters

J Pharmacol Exp Ther· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Jean-Pierre Bongartz, Raymond Stokbroekx, Marcel Van der Aa, Marcel Luyckx, Marc Willems, Marc Ceusters

Bioorg Med Chem Lett· February 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis