Publications by authors named "Robert A Neff"

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Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist.
Brian Lord, Sirak Simavorian, Ian Fraser, Natalie Welty, Ryan Wyatt, Robert A Neff

Br J Pharmacol· September 2025

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The discovery and preclinical pharmacology of JNJ-10450232 (NTM-006), a centrally penetrant, non-opioid structural analog of acetaminophen with comparable analgesic and anti-pyretic properties but no evidence of hepatotoxicity.
Christopher M Flores, John R Carson, Ellen E Codd, Scott L Dax, Edwin K Kuffner, Robert A Neff

Regul Toxicol Pharmacol· April 2025

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Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration.
François P Bischoff, Sven Van Brandt, Marcel Viellevoye, Michel De Cleyn, Michel Surkyn, Robert A Neff

J Med Chem· February 2025

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Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides.
Robert A Neff, Alan D Wickenden

Channels (Austin)· December 2021

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa1.7.
Robert A Neff, Mack Flinspach, Alan Gibbs, Amy Y Shih, Natali A Minassian

J Biol Chem· January 2020

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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
Brian Lord, Leah Aluisio, James R Shoblock, Robert A Neff, Elena I Varlinskaya

J Pharmacol Exp Ther· December 2014

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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
Anindya Bhattacharya, Qi Wang, Hong Ao, James R Shoblock, Brian Lord, Robert A Neff

Br J Pharmacol· October 2013

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Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Natali A Minassian, Alan Gibbs, Amy Y Shih, Yi Liu, Robert A Neff

J Biol Chem· August 2013

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The physiology, pharmacology and future of P2X7 as an analgesic drug target: hype or promise?
Anindya Bhattacharya, Robert A Neff, Alan D Wickenden

Curr Pharm Biotechnol· October 2011

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Respiratory modulation of premotor cardiac vagal neurons in the brainstem.
Olga Dergacheva, Kathleen J Griffioen, Robert A Neff, David Mendelowitz

Respir Physiol Neurobiol· November 2010

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Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteins.
Robert A Neff, William G Conroy, Jeffrey D Schoellerman, Darwin K Berg

J Neurosci· December 2009

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Postsynaptic scaffolds for nicotinic receptors on neurons.
Robert A Neff, David Gomez-Varela, Catarina C Fernandes, Darwin K Berg

Acta Pharmacol Sin· June 2009

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EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons.
Zhaoping Liu, William G Conroy, Tamara M Stawicki, Qiang Nai, Robert A Neff

Mol Cell Neurosci· June 2008

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Sequential interplay of nicotinic and GABAergic signaling guides neuronal development.
Zhaoping Liu, Robert A Neff, Darwin K Berg

Science· December 2006

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Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome.
Robert A Neff, Samuel J Simmens, Cory Evans, David Mendelowitz

J Neurosci· October 2004

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Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons.
Robert A Neff, Jijiang Wang, Sunit Baxi, Cory Evans, David Mendelowitz

Circ Res· September 2003

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