Publications by authors named "Alan D Wickenden"

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Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake.
Kelly L Damm-Ganamet, Clara Moon, Alan D Wickenden, Mark Tichenor, Yunhui Ge

J Clin Invest· November 2025

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Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides.
Robert A Neff, Alan D Wickenden

Channels (Austin)· December 2021

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Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties.
Daniel Knowland, Shenyan Gu, William A Eckert, G Brent Dawe, Jose A Matta, Alan D Wickenden

J Clin Invest· November 2020

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A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2).
Kelly L Damm-Ganamet, Marie-Laure Rives, Alan D Wickenden, Heather M McAllister, Taraneh Mirzadegan

J Biol Chem· March 2020

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa1.7.
Robert A Neff, Mack Flinspach, Alan Gibbs, Amy Y Shih, Natali A Minassian, Alan D Wickenden

J Biol Chem· January 2020

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T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers.
Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Alan D Wickenden

PLoS One· August 2017

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Potentiating SLC transporter activity: Emerging drug discovery opportunities.
Marie-Laure Rives, Jonathan A Javitch, Alan D Wickenden

Biochem Pharmacol· July 2017

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aluisio, Jose Ignacio Andres, Alan D Wickenden

J Med Chem· June 2017

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State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281.
Marie-Laure Rives, Morena Shaw, Bin Zhu, Simon A Hinke, Alan D Wickenden

Mol Pharmacol· December 2016

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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Jason C Rech, Anindya Bhattacharya, Bryan J Branstetter, Christopher J Love, Joseph E Leenaerts, Alan D Wickenden

Bioorg Med Chem Lett· October 2016

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.
Michael P Maher, Nyantsz Wu, Suchitra Ravula, Michael K Ameriks, Brad M Savall, Alan D Wickenden

J Pharmacol Exp Ther· May 2016

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Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Wilson Edwards, Wai-Ping Fung-Leung, Chichi Huang, Ellen Chi, Nancy Wu, Alan D Wickenden

J Biol Chem· August 2014

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Overview of Electrophysiological Techniques.
Alan D Wickenden

Curr Protoc Pharmacol· March 2014

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A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
Joanna Gajewiak, Layla Azam, Julita Imperial, Aleksandra Walewska, Brad R Green, Alan D Wickenden

Proc Natl Acad Sci U S A· February 2014

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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.
Anindya Bhattacharya, Qi Wang, Hong Ao, James R Shoblock, Brian Lord, Alan D Wickenden

Br J Pharmacol· October 2013

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Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Natali A Minassian, Alan Gibbs, Amy Y Shih, Yi Liu, Robert A Neff, Alan D Wickenden

J Biol Chem· August 2013

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Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.
Michael A Letavic, Brian Lord, Francois Bischoff, Natalie A Hawryluk, Serge Pieters, Alan D Wickenden

ACS Med Chem Lett· April 2013

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The physiology, pharmacology and future of P2X7 as an analgesic drug target: hype or promise?
Anindya Bhattacharya, Robert A Neff, Alan D Wickenden

Curr Pharm Biotechnol· October 2011

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Discovery of a novel series of selective HCN1 blockers.
Kelly J McClure, Michael Maher, Nancy Wu, Sandra R Chaplan, William A Eckert, Alan D Wickenden

Bioorg Med Chem Lett· September 2011

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
Michael P Maher, Anindya Bhattacharya, Hong Ao, Nadia Swanson, Nyan-Tsz Wu, Alan D Wickenden

Eur J Pharmacol· August 2011

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N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.
George Amato, Rosemarie Roeloffs, Greg C Rigdon, Brett Antonio, Theresa Mersch, Alan D Wickenden

ACS Med Chem Lett· June 2011

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1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
Alec D Lebsack, Jason C Rech, Bryan J Branstetter, Natalie A Hawryluk, Jeffrey E Merit, Alan D Wickenden

Bioorg Med Chem Lett· December 2010

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Natalie A Hawryluk, Jeffrey E Merit, Alec D Lebsack, Bryan J Branstetter, Michael D Hack, Alan D Wickenden

Bioorg Med Chem Lett· December 2010

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Recent advances in the biology and medicinal chemistry of TRPA1.
Jason C Rech, William A Eckert, Michael P Maher, Tue Banke, Anindya Bhattacharya, Alan D Wickenden

Future Med Chem· May 2010

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Novel KCNQ2/Q3 agonists as potential therapeutics for epilepsy and neuropathic pain.
Paul C Fritch, Grant McNaughton-Smith, George S Amato, James F Burns, C Wesley Eargle, Alan D Wickenden

J Med Chem· January 2010

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