Publications by authors named "Mark Tichenor"

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Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake.
Kelly L Damm-Ganamet, Clara Moon, Alan D Wickenden, Mark Tichenor, Yunhui Ge

J Clin Invest· November 2025

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Holger Babbe, Thomas B Sundberg, Mark Tichenor, Mark Seierstad, Genesis Bacani

Proc Natl Acad Sci U S A· January 2024

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Mark S Tichenor, John J M Wiener, Navin L Rao, Genesis M Bacani, Jianmei Wei

J Med Chem· November 2022

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Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks.
Mark Seierstad, Mark S Tichenor, Renee L DesJarlais, Jim Na, Genesis M Bacani

ACS Med Chem Lett· November 2021

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Mark S Tichenor, John J M Wiener, Navin L Rao, Charlotte Pooley Deckhut, J Kent Barbay

ACS Med Chem Lett· May 2021

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.
Kristi A Leonard, Lisa A Madge, Paul J Krawczuk, Aihua Wang, Kevin D Kreutter, Mark S Tichenor

J Med Chem· March 2020

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The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.
John M Keith, Mark S Tichenor, Richard L Apodaca, Wei Xiao, William M Jones

Bioorg Med Chem Lett· July 2016

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Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.
John M Keith, William M Jones, Mark Tichenor, Jing Liu, Mark Seierstad

ACS Med Chem Lett· December 2015

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Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
Mark S Tichenor, Robin L Thurmond, Jennifer D Venable, Brad M Savall

J Med Chem· September 2015

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Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Mark S Tichenor, John M Keith, William M Jones, Joan M Pierce, Jeff Merit

Bioorg Med Chem Lett· December 2012

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Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.
John M Keith, Rich Apodaca, Mark Tichenor, Wei Xiao, William Jones

ACS Med Chem Lett· October 2012

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Yatakemycin: total synthesis, DNA alkylation, and biological properties.
Mark S Tichenor, Dale L Boger

Nat Prod Rep· April 2008

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Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Mark S Tichenor, Karen S MacMillan, James S Stover, Scott E Wolkenberg, Maria G Pavani

J Am Chem Soc· November 2007

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Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.
Mark S Tichenor, Karen S MacMillan, John D Trzupek, Thomas J Rayl, Inkyu Hwang

J Am Chem Soc· September 2007

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Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
Mark S Tichenor, John D Trzupek, David B Kastrinsky, Futoshi Shiga, Inkyu Hwang

J Am Chem Soc· December 2006

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Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin.
Mark S Tichenor, David B Kastrinsky, Dale L Boger

J Am Chem Soc· July 2004

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Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
Joseph M O'Connor, Seth J Friese, Mark Tichenor

J Am Chem Soc· April 2002

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