Publications by authors named "Brian Gebelein"

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Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver syndrome.
Alyssa F Solano, Kristina Preusse, Brittany Cain, Rebecca Hotz, Parthav Gavini, Brian Gebelein

J Clin Invest· December 2025

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A model of transcriptional bursting dynamics based on coupling between chromatin and enhancer states.
Ofri Axelrod, Udi Binshtok, Brian Gebelein, Hernan Garcia, David Sprinzak

bioRxiv· December 2025

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Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family.
Brittany Cain, Connor Wasmund, Fiona C Rowan, Brian Gebelein

bioRxiv· October 2025

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A dual role for GLI3 signaling in neural crest development.
Simon J Y Han, Vinit Adani, Edward Farrow, Bhavalben Parma, Ching-Fang Chang, Brian A Gebelein

bioRxiv· August 2025

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The ALX4 dimer structure provides insight into how disease alleles impact function.
Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A Kovall, Brian Gebelein

Nat Commun· May 2025

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Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.
Laura Tweedie, Matthew R Riccetti, Brittany Cain, Shenyue Qin, Joseph Salomone, Brian Gebelein

Dis Model Mech· February 2025

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Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface.
Jordan A Webb, Edward Farrow, Brittany Cain, Zhenyu Yuan, Alexander E Yarawsky, Brian Gebelein

Nucleic Acids Res· July 2024

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Cooperative Gsx2-DNA Binding Requires DNA Bending and a Novel Gsx2 Homeodomain Interface.
Jordan A Webb, Edward Farrow, Brittany Cain, Zhenyu Yuan, Alexander E Yarawsky, Brian Gebelein

bioRxiv· December 2023

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Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data.
Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Brian Gebelein

Nucleic Acids Res· July 2023

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Homeodomain complex formation and biomolecular condensates in Hox gene regulation.
Joseph Salomone, Edward Farrow, Brian Gebelein

Semin Cell Dev Biol· December 2022

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A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects.
Ellen K Gagliani, Lisa M Gutzwiller, Yi Kuang, Yoshinobu Odaka, Phillipp Hoffmeister, Brian Gebelein

PLoS Genet· August 2022

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Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.
Ángela Del Águila, Mike Adam, Kristy Ullom, Nicholas Shaw, Shenyue Qin, Brian Gebelein

Development· March 2022

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A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia.
Derek E Neilson, Michael Zech, Robert B Hufnagel, Jesse Slone, Xinjian Wang, Brian Gebelein

Mov Disord· February 2022

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Mechanisms Underlying Hox-Mediated Transcriptional Outcomes.
Brittany Cain, Brian Gebelein

Front Cell Dev Biol· November 2021

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Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.
Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M Gutzwiller, Brian Gebelein

PLoS Genet· September 2021

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Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer.
Nicole Oatman, Nupur Dasgupta, Priyanka Arora, Kwangmin Choi, Mruniya V Gawali, Brian Gebelein

Sci Adv· February 2021

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Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.
Joseph Salomone, Shenyue Qin, Temesgen D Fufa, Brittany Cain, Edward Farrow, Brian Gebelein

Genes Dev· January 2021

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Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.
Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Brian Gebelein

Elife· October 2020

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Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.
Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Brian Gebelein

PLoS Biol· October 2020

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Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence.
Kaushik Roychoudhury, Joseph Salomone, Shenyue Qin, Brittany Cain, Mike Adam, Brian Gebelein

Development· April 2020

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Enhancer architecture sensitizes cell specific responses to gene dose via a bind and discard mechanism.
Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Brian Gebelein

Elife· April 2020

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A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Xinghao Zhang, Patrick S McGrath, Joseph Salomone, Mohamed Rahal, Heather A McCauley, Brian Gebelein

Dev Cell· August 2019

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The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.
Arya Zandvakili, Juli D Uhl, Ian Campbell, Joseph Salomone, Yuntao Charlie Song, Brian Gebelein

Dev Biol· January 2019

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Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity.
Arya Zandvakili, Ian Campbell, Lisa M Gutzwiller, Matthew T Weirauch, Brian Gebelein

PLoS Genet· April 2018

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Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
Zirong Gu, John Kalambogias, Shin Yoshioka, Wenqi Han, Zhuo Li, Brian Gebelein

Science· July 2017

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