Publications by authors named "Brian Geist"

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Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling.
Beverly Knight, Brinda Tammara, Nishit B Modi, Shannon Dallas, Saro Mardirosian, Brian Geist

Dermatol Ther (Heidelb)· September 2025

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In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension.
Tobias G Schips, Karl W Kavalkovich, Lai-Ming Yung, Salam Ibrahim, Makhosi Edmondson, Brian Geist

PLoS One· July 2025

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JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G.
Nataša Obermajer, Adam Zwolak, Kelly van de Ven, Shana Versmissen, Krista Menard, Brian Geist

iScience· March 2025

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Best Practices and Recommendations for Non-Liquid Matrices Bioanalysis.
Faye Vazvaei-Smith, Wenkui Li, Omar S Barnaby, Sanjeev Bhardwaj, Juyao Dong, Brian Geist

AAPS J· March 2025

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Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability.
Shalom D Goldberg, Tero Satomaa, Olulanu Aina, Olli Aitio, Krista Burke, Brian Geist

Mol Cancer Ther· November 2024

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A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin-Schmidt

Clin Transl Sci· August 2023

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Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis.
Suzanne Edavettal, Pilar Cejudo-Martin, Bidisha Dasgupta, Danlin Yang, Matthew D Buschman, Brian Geist

Med· December 2022

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Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment.
Ian White, Ninkka Tamot, Rajitha Doddareddy, Jason Ho, Qun Jiao, Brian Geist

MAbs· November 2021

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Translational PK/PD and model-informed development of JNJ-67842125, a F reversal agent for JNJ-64179375, a long-acting thrombin inhibitor.
Vivaswath S Ayyar, Pharavee Jaiprasart, Brian Geist, Zheng Huang Devine, Martin Case

Br J Pharmacol· October 2021

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A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model.
Songmao Zheng, Jin Niu, Brian Geist, Damien Fink, Zhenhua Xu

MAbs· August 2021

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Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A.
Songmao Zheng, Fang Shen, Brian Jones, Damien Fink, Brian Geist

MAbs· May 2021

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Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics.
Bharathikumar Vellalore Maruthachalam, Adam Zwolak, Xiefan Lin-Schmidt, Edward Keough, Ninkka Tamot, Brian Geist

MAbs· February 2021

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Application of multiplexed pharmacokinetic immunoassay to quantify drug forms and coadministered biologics.
Nicole Woodbury, Eric Bald, Brian Geist, Tong-Yuan Yang

Bioanalysis· December 2019

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Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice.
Xi Chen, Xiling Jiang, Rajitha Doddareddy, Brian Geist, Thomas McIntosh

J Pharmacol Exp Ther· April 2018

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Radiation stability of visible and near-infrared optical and magneto-optical properties of terbium gallium garnet crystals.
Brian Geist, Reginald Ronningen, Andreas Stolz, Georg Bollen, Vladimir Kochergin

Appl Opt· April 2015

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Matrix effect in ligand-binding assay: the importance of evaluating emerging technologies.
Rebecca M Crisino, Linlin Luo, Brian Geist, Jad Zoghbi, Franklin Spriggs

Bioanalysis· April 2014

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A novel approach to evaluate the pharmacokinetic biocomparability of a monoclonal antibody derived from two different cell lines using simultaneous crossover design.
Chao Han, Thomas S McIntosh, Brian J Geist, Trina Jiao, Thomas A Puchalski

AAPS J· January 2014

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A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines.
Brian J Geist, Darryl Davis, Thomas McIntosh, Tong-Yuan Yang, Kenneth Goldberg

MAbs· July 2013

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Characterization of critical reagents in ligand-binding assays: enabling robust bioanalytical methods and lifecycle management.
Brian J Geist, Adrienne Clements Egan, Tong-Yuan Yang, Yuxin Dong, Gopi Shankar

Bioanalysis· January 2013

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Conference report: Bioanalysis highlights from the 2012 American Association of Pharmaceutical Scientists National Biotechnology Conference.
Rebecca M Crisino, Brian Geist, Jian Li

Bioanalysis· September 2012

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Preliminary dielectric measurement and analysis protocol for determining the melting temperature and binding energy of short sequences of DNA in solution.
William B Spillman, Ramazan Asmatulu, Christelle F Jullian, Brian Geist, Richard O Claus

Biotechnol J· February 2008

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Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins.
Bryan D Dickerson, Brian L Geist, William B Spillman, John L Robertson

Appl Opt· November 2007

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Thermal cycling and the optical and electrical characterization of self-assembled multilayer nile blue A-gold thin films.
Brian Geist, William B Spillman, Richard O Claus

Appl Opt· October 2005

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