Publications by authors named "Brian Hasinoff"

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Mechanisms of the Cardiac Myocyte-Damaging Effects of Dasatinib.
Brian B Hasinoff, Daywin Patel

Cardiovasc Toxicol· August 2020

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A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition.
Brian B Hasinoff, Daywin Patel, Xing Wu

Toxicol Appl Pharmacol· July 2020

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The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane.
Brian B Hasinoff, Daywin Patel, Xing Wu

Cardiovasc Toxicol· June 2020

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Myocyte-Damaging Effects and Binding Kinetics of Boronic Acid and Epoxyketone Proteasomal-Targeted Drugs.
Brian B Hasinoff, Daywin Patel

Cardiovasc Toxicol· December 2018

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Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs.
Dinghua Liang, Xing Wu, Brian B Hasinoff, David E Herbert, Geoffrey K Tranmer

Molecules· August 2018

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Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome.
Brian B Hasinoff

Arch Biochem Biophys· February 2018

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Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity.
Brian B Hasinoff, Daywin Patel

Arch Biochem Biophys· November 2017

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Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib.
Brian B Hasinoff, Daywin Patel, Xing Wu

Cardiovasc Toxicol· July 2017

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The Myocyte-Damaging Effects of the BCR-ABL1-Targeted Tyrosine Kinase Inhibitors Increase with Potency and Decrease with Specificity.
Brian B Hasinoff, Daywin Patel, Xing Wu

Cardiovasc Toxicol· July 2017

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Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.
Brian B Hasinoff, Xing Wu, Daywin Patel, Ragu Kanagasabai, Soumendrakrishna Karmahapatra

J Pharmacol Exp Ther· February 2016

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Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
Arun A Yadav, Gaik-Lean Chee, Xing Wu, Daywin Patel, Jack C Yalowich, Brian B Hasinoff

Bioorg Med Chem· July 2015

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Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II).
Brian B Hasinoff, Xing Wu, Arun A Yadav, Daywin Patel, Hui Zhang

Biochem Pharmacol· February 2015

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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
Arun A Yadav, Xing Wu, Daywin Patel, Jack C Yalowich, Brian B Hasinoff

Bioorg Med Chem· November 2014

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The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II).
Brian B Hasinoff, Arun A Yadav, Daywin Patel, Xing Wu

J Inorg Biochem· August 2014

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Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II).
Arun A Yadav, Daywin Patel, Xing Wu, Brian B Hasinoff

J Inorg Biochem· September 2013

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The dual-targeted HER1/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin.
Brian B Hasinoff, Daywin Patel, Xing Wu

Cardiovasc Toxicol· March 2013

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The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.
Brian B Hasinoff, Xing Wu, John L Nitiss, Ragu Kanagasabai, Jack C Yalowich

Biochem Pharmacol· December 2012

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The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.
Jack C Yalowich, Xing Wu, Rui Zhang, Ragu Kanagasabai, Marisa Hornbaker, Brian B Hasinoff

Biochem Pharmacol· July 2012

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Chemical reactivity and microbicidal action of bethoxazin.
Gaik-Lean Chee, Bharat Bhattarai, R Daniel Gietz, Samaa Alrushaid, John L Nitiss, Brian B Hasinoff

Bioorg Med Chem· February 2012

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A multifaceted evaluation of imatinib-induced cardiotoxicity in the rat.
Eugene H Herman, Alan Knapton, Elliot Rosen, Karol Thompson, Barry Rosenzweig, Brian Hasinoff

Toxicol Pathol· December 2011

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents.
Rui Zhang, Xing Wu, Jack C Yalowich, Brian B Hasinoff

Bioorg Med Chem· December 2011

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Cadmium is a catalytic inhibitor of DNA topoisomerase II.
Xing Wu, Jack C Yalowich, Brian B Hasinoff

J Inorg Biochem· June 2011

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The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro.
Brian B Hasinoff, Daywin Patel

Toxicol Appl Pharmacol· December 2010

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Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents.
Rui Zhang, Xing Wu, Lynn J Guziec, Frank S Guziec, Gaik-Lean Chee, Brian B Hasinoff

Bioorg Med Chem· June 2010

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Kinamycin F downregulates cyclin D3 in human leukemia K562 cells.
Kimberley A O'Hara, Gary I Dmitrienko, Brian B Hasinoff

Chem Biol Interact· March 2010

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