Publications by authors named "Brian Hrupka"

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The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
Andree Schmidt, Brian Hrupka, Frauke van Bebber, Sanjay Sunil Kumar, Xiao Feng

J Clin Invest· June 2024

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JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
Frederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander, Nigel Austin, Herman Borghys, Brian Hrupka

J Med Chem· October 2021

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Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M Munro, Jenny M Gunnersen, Brian J Hrupka

Mol Neurodegener· October 2016

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JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.
John R Atack, Brian C Shook, Stefanie Rassnick, Paul F Jackson, Kenneth Rhodes, Brian Hrupka

ACS Chem Neurosci· October 2014

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Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia.
Marie Pollard, Christophe Varin, Brian Hrupka, Darrel J Pemberton, Thomas Steckler

Behav Brain Res· February 2012

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Evidence that PGE2 in the dorsal and median raphe nuclei is involved in LPS-induced anorexia in rats.
Brigitte S Kopf, Wolfgang Langhans, Nori Geary, Brian Hrupka, Lori Asarian

Pharmacol Biochem Behav· September 2011

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Subdiaphragmatic vagal deafferentation fails to block the anorectic effect of hydroxycitrate.
Monika Leonhardt, Brian J Hrupka, Wolfgang Langhans

Physiol Behav· September 2004

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Evidence for a role of the 5-HT2C receptor in central lipopolysaccharide-, interleukin-1 beta-, and leptin-induced anorexia.
Claudia von Meyenburg, Wolfgang Langhans, Brian J Hrupka

Pharmacol Biochem Behav· March 2003

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Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor.
Claudia von Meyenburg, Wolfgang Langhans, Brian J Hrupka

Pharmacol Biochem Behav· January 2003

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Hypothalamic implants of dilute estradiol fail to reduce feeding in ovariectomized rats.
Brian J Hrupka, Gerard P Smith, Nori Geary

Physiol Behav· November 2002

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