Publications by authors named "Kenneth Rhodes"

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Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy.
Jeonghoon Choi, Hiroaki Kii, Justin Nelson, Yoichi Yamazaki, Fumiki Yanagawa, Kenneth Rhodes

SLAS Technol· April 2023

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Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease.
Waseem K Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J Rhodes

PLoS One· December 2022

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Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Silke Nuber, Chee Yeun Chung, Daniel F Tardiff, Pascal A Bechade, Thomas D McCaffery, Kenneth J Rhodes

Neurotherapeutics· July 2022

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Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease.
Daniel F Tardiff, Matthew Lucas, Iwona Wrona, Belle Chang, Chee Yeun Chung, Kenneth J Rhodes

Mol Neurobiol· April 2022

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A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Silke Nuber, Chee Yeun Chung, Daniel F Tardiff, Pascal A Bechade, Thomas D McCaffery, Kenneth J Rhodes

Neurotherapeutics· April 2022

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Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.
Benjamin M Vincent, Daniel F Tardiff, Jeff S Piotrowski, Rebecca Aron, Matthew C Lucas, Kenneth J Rhodes

Cell Rep· December 2018

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Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Edward Y S Lin, Laura F Silvian, Douglas J Marcotte, Charles C Banos, Flora Jow, Kenneth J Rhodes

Sci Rep· September 2018

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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
Robert H Scannevin, Richard Alexander, Tara Mezzasalma Haarlander, Sharon L Burke, Monica Singer, Kenneth J Rhodes

J Biol Chem· October 2017

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Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H Weinreb, Leslie Williams, Kenneth Rhodes

Nature· June 2017

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The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H Weinreb, Leslie Williams, Kenneth Rhodes

Nature· September 2016

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Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms.
Melanie S Brennan, Hiral Patel, Norm Allaire, Alice Thai, Patrick Cullen, Kenneth J Rhodes

Antioxid Redox Signal· June 2016

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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Robert H Scannevin, Sowmya Chollate, Melanie S Brennan, Pamela A Snodgrass-Belt, Hairuo Peng, Kenneth J Rhodes

Neuropharmacology· April 2016

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Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.
Melanie S Brennan, Maria F Matos, Bing Li, Xiaoping Hronowski, Benbo Gao, Kenneth J Rhodes

PLoS One· February 2016

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JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.
John R Atack, Brian C Shook, Stefanie Rassnick, Paul F Jackson, Kenneth Rhodes

ACS Chem Neurosci· October 2014

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Synapto-depressive effects of amyloid beta require PICK1.
Stephanie Alfonso, Helmut W Kessels, Charles C Banos, Timothy R Chan, Edward T Lin, Kenneth J Rhodes

Eur J Neurosci· April 2014

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Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.
Brian C Shook, Devraj Chakravarty, J Kent Barbay, Aihua Wang, Kristi Leonard, Kenneth Rhodes

Bioorg Med Chem Lett· May 2013

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Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Robert H Scannevin, Sowmya Chollate, Mi-young Jung, Melanie Shackett, Hiral Patel, Kenneth J Rhodes

J Pharmacol Exp Ther· April 2012

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Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.
Brian C Shook, Stefanie Rassnick, Nathaniel Wallace, Jeffrey Crooke, Mark Ault, Kenneth Rhodes

J Med Chem· February 2012

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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Zhili Xin, Hairuo Peng, Andrew Zhang, Tina Talreja, Gnanasambandam Kumaravel, Kenneth J Rhodes

Bioorg Med Chem Lett· December 2011

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Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy.
Lawrence J Wilson, Bingbing Wang, Shyh-Ming Yang, Robert H Scannevin, Sharon L Burke, Kenneth J Rhodes

Bioorg Med Chem Lett· November 2011

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Hairuo Peng, Tina Talreja, Zhili Xin, J Hernan Cuervo, Gnanasambandam Kumaravel, Kenneth J Rhodes

ACS Med Chem Lett· October 2011

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Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
Heng-Keang Lim, Jie Chen, Carlo Sensenhauser, Kevin Cook, Robert Preston, Kenneth Rhodes

Chem Res Toxicol· July 2011

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Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination.
Sha Mi, Xinhua Lee, Yinghui Hu, Benxiu Ji, Zhaohui Shao, Kenneth Rhodes

Nat Med· July 2011

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In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.
Brian C Shook, Stefanie Rassnick, Melville C Osborne, Scott Davis, Lori Westover, Kenneth Rhodes

J Med Chem· November 2010

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Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
Brian C Shook, Stefanie Rassnick, Daniel Hall, Kenneth C Rupert, Geoffrey R Heintzelman, Kenneth Rhodes

Bioorg Med Chem Lett· May 2010

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