Publications by authors named "Brian Lacey"

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Brian M Lacey

J Med Chem· April 2022

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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
Ryan V Quiroz, Michael H Reutershan, Sebastian E Schneider, David Sloman, Brian M Lacey

J Med Chem· April 2021

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Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Brandon A Vara, Samuel M Levi, Abdelghani Achab, David A Candito, Xavier Fradera, Brian M Lacey

ACS Med Chem Lett· April 2021

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Identification of Potent Reverse Indazole Inhibitors for HPK1.
Elsie C Yu, Joey L Methot, Xavier Fradera, Charles A Lesburg, Brian M Lacey

ACS Med Chem Lett· March 2021

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
Brian M Lacey, Zangwei Xu, Xiaomei Chai, Jason Laskey, Xavier Fradera

SLAS Discov· January 2021

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Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function.
Yun Wang, Kelvin Zhang, Peter Georgiev, Steven Wells, Haiyan Xu, Brian M Lacey

PLoS One· January 2021

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Seasonality of Infections and Their Relationship with Honey Bee Populations, Food Stores, and Survivorship in a North American Region.
Berna Emsen, Alvaro De la Mora, Brian Lacey, Les Eccles, Paul G Kelly

Vet Sci· September 2020

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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
Rachel L Palte, Sebastian E Schneider, Michael D Altman, Robert P Hayes, Shuhei Kawamura, Brian M Lacey

ACS Med Chem Lett· September 2020

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An orally available non-nucleotide STING agonist with antitumor activity.
Bo-Sheng Pan, Samanthi A Perera, Jennifer A Piesvaux, Jeremy P Presland, Gottfried K Schroeder, Brian M Lacey

Science· August 2020

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Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations.
Zachary Z Brown, Claudio Mapelli, Iman Farasat, Alycia V Shoultz, Scott A Johnson, Brian M Lacey

J Org Chem· February 2020

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Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
Tony Siu, Michael D Altman, Gretchen A Baltus, Matthew Childers, J Michael Ellis, Brian M Lacey

ACS Med Chem Lett· January 2019

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Higher prevalence and levels of Nosema ceranae than Nosema apis infections in Canadian honey bee colonies.
Berna Emsen, Ernesto Guzman-Novoa, Mollah Md Hamiduzzaman, Les Eccles, Brian Lacey

Parasitol Res· January 2016

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Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.
Craig J McPherson, Lisa M Aschenbrenner, Brian M Lacey, Kelly C Fahnoe, Margaret M Lemmon

Antimicrob Agents Chemother· December 2012

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Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
Krisztina M Papp-Wallace, Baui Senkfor, Julian Gatta, Weirui Chai, Magdalena A Taracila, Brian M Lacey

Antimicrob Agents Chemother· November 2012

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Distinctive attributes of β-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics.
Seungil Han, Nicole Caspers, Richard P Zaniewski, Brian M Lacey, Andrew P Tomaras

J Am Chem Soc· December 2011

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Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Seungil Han, Richard P Zaniewski, Eric S Marr, Brian M Lacey, Andrew P Tomaras

Proc Natl Acad Sci U S A· December 2010

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Selenium in thioredoxin reductase: a mechanistic perspective.
Brian M Lacey, Brian E Eckenroth, Stevenson Flemer, Robert J Hondal

Biochemistry· December 2008

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Synthesis of peptide substrates for mammalian thioredoxin reductase.
Stevenson Flemer, Brian M Lacey, Robert J Hondal

J Pept Sci· May 2008

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Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis.
Brian E Eckenroth, Brian M Lacey, Adam P Lothrop, Katharine M Harris, Robert J Hondal

Biochemistry· August 2007

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Characterization of mitochondrial thioredoxin reductase from C. elegans.
Brian M Lacey, Robert J Hondal

Biochem Biophys Res Commun· August 2006

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