Publications by authors named "Brian Leaker"

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Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma.
Horace Rhee, Lindsay M Henderson, Rebecca N Bauer, Kit Wong, Tracy L Staton, Brian Leaker

Allergy· November 2024

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Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD.
Phillip D Monk, Jody L Brookes, Victoria J Tear, Toby N Batten, Clare Newall, Brian Leaker

Respir Res· May 2024

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COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum.
Dave Singh, Michele Bassi, Deborah Balzano, Germano Lucci, Aida Emirova, Brian Leaker

J Cell Mol Med· January 2021

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COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition.
Dave Singh, Henrik Watz, Kai Michael Beeh, Oliver Kornmann, Brian Leaker

Eur Respir J· August 2020

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Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.
Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Brian Leaker

Respir Res· March 2020

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Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study.
Brian R Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson

Respir Res· December 2019

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Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD.
Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker

Respir Res· August 2019

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Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease.
Brian R Leaker, Dave Singh, Grant C Nicholson, Blanka Hezelova, Thomas Goodin

Respir Res· June 2019

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Comparison of the effect of beclometasone/formoterol in asthma patients after methacholine-induced bronchoconstriction: A noninferiority study using metered dose vs. dry powder inhaler.
Dave Singh, Frans van den Berg, Brian Leaker, Massimo Corradi, Sunny Jabbal

Br J Clin Pharmacol· April 2019

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The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function.
John F Golding, Keith A Wesnes, Brian R Leaker

Br J Clin Pharmacol· July 2018

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Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.
Richard J Russell, Latifa Chachi, J Mark FitzGerald, Vibeke Backer, Ronald Olivenstein, Brian Leaker

Lancet Respir Med· July 2018

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Conditional neuromodulation of neurogenic detrusor overactivity using transrectal stimulation in patients with spinal cord injury: A proof of principle study.
Sarah Louise Knight, Nuwani Edirisinghe, Brian Leaker, Judith Susser, Michael Duncan Craggs

Neurourol Urodyn· January 2018

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Design of sEMG assembly to detect external anal sphincter activity: a proof of concept.
Arsam Shiraz, Brian Leaker, Charles Alexander Mosse, Eskinder Solomon, Michael Craggs

Physiol Meas· October 2017

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Optimization of a wearable pudendal nerve stimulator using computational models.
Arsam N Shiraz, Brian Leaker, Andreas Demosthenous

Annu Int Conf IEEE Eng Med Biol Soc· October 2016

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Minimizing Stimulus Current in a Wearable Pudendal Nerve Stimulator Using Computational Models.
Arsam N Shiraz, Michael Craggs, Brian Leaker, Andreas Demosthenous

IEEE Trans Neural Syst Rehabil Eng· April 2016

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Using magnetic resonance imaging to quantify the inflammatory response following allergen challenge in allergic rhinitis.
Brian R Leaker, Glenis Scadding, C Richard Jones, Peter J Barnes

Immun Inflamm Dis· December 2015

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The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma.
Brian R Leaker, Brian O'Connor, Dave Singh, Peter J Barnes

J Allergy Clin Immunol· August 2015

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Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease.
Brian R Leaker, Peter J Barnes, C Richard Jones, Ahmet Tutuncu, Dave Singh

Br J Clin Pharmacol· March 2015

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The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
Brian R Leaker, Dave Singh, Ferhana Y Ali, Peter J Barnes, Brian O'Connor

BMC Pulm Med· October 2014

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Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist.
Brian R Leaker, Peter J Barnes, Brian O'Connor

Respir Res· December 2013

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Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial.
Brian J O'Connor, Sara Collarini, Gianluigi Poli, Caterina Brindicci, Monica Spinola, Brian Leaker

BMC Pulm Med· December 2011

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Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial.
Brian R Leaker, B O'Connor, Trevor T Hansel, Peter J Barnes, Lixen Meng

J Nucl Cardiol· July 2008

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Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants.
Edward M Erin, Gavin R Jenkins, Onn Min Kon, Angela S Zacharasiewicz, Grant C Nicholson, Brian R Leaker

Am J Respir Crit Care Med· January 2008

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The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma.
Edward M Erin, Brian R Leaker, Grant C Nicholson, Andrew J Tan, Linda M Green

Am J Respir Crit Care Med· October 2006

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