Publications by authors named "Brian Marsden"

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Early lymph node T follicular helper cell signalling hub drives influenza vaccine response in an ancestrally diverse cohort.
Jacqueline H Y Siu, Sofia Coelho, Aime Palomeras, Sandra Belij-Rammerstorfer, Ninisha Barman, Brian D Marsden

EBioMedicine· December 2025

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CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue.
Feng Liu, Hui Shi, Jason D Turner, Rachel Anscombe, Jiaqi Li, Brian D Marsden

Ann Rheum Dis· July 2025

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MolSnapper: Conditioning Diffusion for Structure-Based Drug Design.
Yael Ziv, Fergus Imrie, Brian Marsden, Charlotte M Deane

J Chem Inf Model· May 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Brian D Marsden

RSC Med Chem· February 2025

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Robustly interrogating machine learning-based scoring functions: what are they learning?
Guy Durant, Fergus Boyles, Kristian Birchall, Brian Marsden, Charlotte M Deane

Bioinformatics· February 2025

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EEFSEC deficiency: A selenopathy with early-onset neurodegeneration.
Lucia Laugwitz, Rebecca Buchert, Patricio Olguín, Mehrdad A Estiar, Mihaela Atanasova, Brian Marsden

Am J Hum Genet· January 2025

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Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology.
Matteo P Ferla, Rubén Sánchez-García, Rachael E Skyner, Stefan Gahbauer, Jenny C Taylor, Brian D Marsden

J Cheminform· January 2025

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A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Tom Thomas, Matthias Friedrich, Charlotte Rich-Griffin, Mathilde Pohin, Devika Agarwal, Brian Marsden

Nat Immunol· November 2024

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Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.
Yun Deng, Thomas A Perry, Philippa Hulley, Rose A Maciewicz, Joanna Mitchelmore, Brian Marsden

PLoS One· November 2024

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A data science roadmap for open science organizations engaged in early-stage drug discovery.
Kristina Edfeldt, Aled M Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, Brian D Marsden

Nat Commun· July 2024

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Improving the representativeness of UK's national COVID-19 Infection Survey through spatio-temporal regression and post-stratification.
Koen B Pouwels, David W Eyre, Thomas House, Ben Aspey, Philippa C Matthews, Brian D Marsden

Nat Commun· June 2024

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Persistence of SARS-CoV-2 antibodies over 18 months following infection: UK Biobank COVID-19 Serology Study.
Jelena Bešević, Ben Lacey, Howard Callen, Wemimo Omiyale, Megan Conroy, Brian D Marsden

J Epidemiol Community Health· November 2023

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Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Alistair T Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M Taylor, Mona Hashim, Brian Marsden

Genome Med· November 2023

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Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity.
Clare E West, Mohd Karim, Maria J Falaguera, Leo Speidel, Charlotte J Green, Brian D Marsden

Sci Data· September 2023

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Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.
Kelsey N Thompson, Kevin S Bonham, Nicholas E Ilott, Graham J Britton, Paula Colmenero, Brian Marsden

Sci Transl Med· July 2023

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Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK.
Jia Wei, Philippa C Matthews, Nicole Stoesser, John N Newton, Ian Diamond, Brian D Marsden

Nat Commun· May 2023

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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications.
Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Brian D Marsden

J Clin Immunol· February 2023

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COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas.
Dapeng Wang, Vinod Kumar, Katie L Burnham, Alexander J Mentzer, Brian D Marsden

Nucleic Acids Res· January 2023

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Venus: Elucidating the Impact of Amino Acid Variants on Protein Function Beyond Structure Destabilisation.
Matteo P Ferla, Alistair T Pagnamenta, Leonidas Koukouflis, Jenny C Taylor, Brian D Marsden

J Mol Biol· June 2022

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SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection.
Jia Wei, Philippa C Matthews, Nicole Stoesser, Ian Diamond, Ruth Studley, Brian D Marsden

Nat Commun· June 2022

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Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.
Jia Wei, Koen B Pouwels, Nicole Stoesser, Philippa C Matthews, Ian Diamond, Brian D Marsden

Nat Med· May 2022

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FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in S2 Cells.
Jesse A Coker, Vittorio L Katis, Michael Fairhead, Anja Schwenzer, Stine B Clemmensen, Brian D Marsden

Front Bioeng Biotechnol· May 2022

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Fragment Hotspot Mapping to Identify Selectivity-Determining Regions between Related Proteins.
Mihaela D Smilova, Peter R Curran, Chris J Radoux, Frank von Delft, Jason C Cole, Brian D Marsden

J Chem Inf Model· January 2022

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Target 2035 - update on the quest for a probe for every protein.
Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Brian D Marsden

RSC Med Chem· January 2022

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Anti-spike antibody response to natural SARS-CoV-2 infection in the general population.
Jia Wei, Philippa C Matthews, Nicole Stoesser, Thomas Maddox, Luke Lorenzi, Brian D Marsden

Nat Commun· October 2021

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