Publications by authors named "Brian N Cook"

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Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.
Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A Hoffman, Brian N Cook

Science· November 2025

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CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.
Nuruddeen D Lewis, Akalushi Muthukumarana, Steven E Fogal, Laura Corradini, Dimitria E Stefanopoulos, Brian N Cook

PLoS One· June 2015

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Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.
Joshua C Horan, Sulagna Sanyal, Younggi Choi, Melissa Hill-Drzewi, Lori Patnaude, Brian N Cook

Bioorg Med Chem Lett· October 2014

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5-Aminomethylbenzimidazoles as potent ITK antagonists.
Doris Riether, Renée Zindell, Jennifer A Kowalski, Brian N Cook, Jörg Bentzien

Bioorg Med Chem Lett· March 2009

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Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.
Brian N Cook, Jörg Bentzien, Andre White, Peter A Nemoto, Ji Wang

Bioorg Med Chem Lett· February 2009

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Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Kevin J Moriarty, Michael Winters, Lei Qiao, Declan Ryan, Renee DesJarlis, Brian N Cook

Bioorg Med Chem Lett· October 2008

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Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Kevin J Moriarty, Hidenori Takahashi, Steven S Pullen, Hnin Hnin Khine, Rosemarie H Sallati, Brian N Cook

Bioorg Med Chem Lett· October 2008

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Chemical approaches to the investigation of cellular systems.
Brian N Cook, Carolyn R Bertozzi

Bioorg Med Chem· April 2002

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Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.
John W Kehoe, Dustin J Maly, Dawn E Verdugo, Joshua I Armstrong, Brian N Cook

Bioorg Med Chem Lett· February 2002

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