Publications by authors named "Bruce D Given"

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Virological Insights from ARC-520 siRNA and Entecavir Treated Chronically HBV-Infected Patients and Chimpanzees.
Christine I Wooddell, Lung Yi Mak, Wai-Kay Seto, Bruce D Given, Man-Fung Yuen

Microorganisms· July 2025

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Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA.
Christine I Wooddell, Dean Sanders, Zhao Xu, Lung-Yi Mak, Thomas Schluep, Bruce D Given

Viruses· December 2024

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A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.
Lung-Yi Mak, Ed Gane, Christian Schwabe, Ki Tae Yoon, Jeong Heo, Bruce D Given

J Hepatol· April 2023

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Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB.
Man-Fung Yuen, Stephen Locarnini, Tien Huey Lim, Simone I Strasser, William Sievert, Bruce D Given

J Hepatol· November 2022

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Fazirsiran for Liver Disease Associated with Alpha-Antitrypsin Deficiency.
Pavel Strnad, Mattias Mandorfer, Gourab Choudhury, William Griffiths, Christian Trautwein, Bruce D Given

N Engl J Med· August 2022

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Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment.
Man-Fung Yuen, Danny Ka-Ho Wong, Thomas Schluep, Ching-Lung Lai, Carlo Ferrari, Bruce D Given

Gut· April 2022

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RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies.
Christine I Wooddell, Adam J Gehring, Man-Fung Yuen, Bruce D Given

Viruses· March 2021

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RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection.
Man-Fung Yuen, Ingolf Schiefke, Jung-Hwan Yoon, Sang Hoon Ahn, Jeong Heo, Bruce D Given

Hepatology· July 2020

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Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease.
Christine I Wooddell, Keith Blomenkamp, Ryan M Peterson, Vladimir M Subbotin, Christian Schwabe, Bruce D Given

JCI Insight· June 2020

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Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.
Alice M Turner, Jan Stolk, Robert Bals, Jason D Lickliter, James Hamilton, Bruce D Given

J Hepatol· August 2018

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RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.
Christine I Wooddell, Man-Fung Yuen, Henry Lik-Yuen Chan, Robert G Gish, Stephen A Locarnini, Bruce D Given

Sci Transl Med· September 2017

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Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.
Thomas Schluep, Jason Lickliter, James Hamilton, David L Lewis, Ching-Lung Lai, Bruce D Given

Clin Pharmacol Drug Dev· July 2017

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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.
Robert G Gish, Bruce D Given, Ching-Lung Lai, Stephen A Locarnini, Johnson Y N Lau

Antiviral Res· September 2015

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Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.
Robert G Gish, Man-Fung Yuen, Henry Lik Yuen Chan, Bruce D Given, Ching-Lung Lai

Antiviral Res· September 2015

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