Publications by authors named "William Griffiths"

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Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.
Hye Sun Kuehn, Agustin Alejandro Gil Silva, Natchanun Klangkalya, Ana Esteve-Sole, Shubham Goel, William Jh Griffiths

Blood Adv· December 2025

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Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis.
Lauren Griffiths, Kristen Hawkins, Eylan Yutuc, Roberto Angelini, Racheal Fosuah, William J Griffiths

Brain Pathol· September 2025

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Broadband Limits on Stochastic Length Fluctuations from a Pair of Table-Top Interferometers.
Abhinav Patra, Lorenzo Aiello, Aldo Ejlli, William L Griffiths, Alasdair L James

Phys Rev Lett· September 2025

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Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency.
Natalia Brzozowska, Lily Y D Wu, Vera Khodzhaeva, William J Griffiths, Adam Duckworth

Nat Genet· April 2025

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Longitudinal Evaluation of Individuals With Severe Alpha-1 Antitrypsin Deficiency (Pi∗ZZ Genotype).
Malin Fromme, Audrey Payancé, Mattias Mandorfer, Katrine H Thorhauge, Monica Pons, William J Griffiths

Gastroenterology· February 2025

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The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data.
Dominik Kopczynski, Christer S Ejsing, Jeffrey G McDonald, Takeshi Bamba, Erin S Baker, William J Griffiths

J Lipid Res· September 2024

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Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease.
Ria Schönauer, Dana Sierks, Melissa Boerrigter, Tabinda Jawaid, Lea Caroff, William J Griffiths

Gastroenterology· May 2024

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Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development.
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina Pikuleva

Brain· May 2024

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Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ).
Malin Fromme, Karim Hamesch, Carolin V Schneider, Mattias Mandorfer, Monica Pons, William J Griffiths

Clin Gastroenterol Hepatol· February 2024

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LIPID MAPS: update to databases and tools for the lipidomics community.
Matthew J Conroy, Robert M Andrews, Simon Andrews, Lauren Cockayne, Edward A Dennis, William J Griffiths

Nucleic Acids Res· January 2024

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Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.
James Hennegan, Aled H Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J M Bartley, William J Griffiths

iScience· January 2024

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CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.
María Latorre-Leal, Patricia Rodriguez-Rodriguez, Luca Franchini, Orestis Nikolidakis, Makrina Daniilidou, William J Griffiths

Sci Adv· January 2024

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Mass Spectrometry Imaging of Cholesterol and Oxysterols.
William J Griffiths, Eylan Yutuc, Yuqin Wang

Adv Exp Med Biol· December 2023

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Where does genetic testing fit in the diagnostic pathway of patients with cryptogenic cirrhosis?
Jeremy S Nayagam, Steven Masson, James W Ferguson, William Griffiths, Deepak Joshi

J Hepatol· November 2023

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Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities.
Makrina Daniilidou, Francesca Eroli, Vilma Alanko, Julen Goikolea, Maria Latorre-Leal, William J Griffiths

Brain Commun· August 2023

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Magnetic Resonance Liver Iron Concentration Can Guide Venesection Decision-Making in Hyperferritinemia.
Meha Bhuva, Ilse Patterson, Edmund M Godfrey, David J Bowden, William J H Griffiths

Dig Dis Sci· June 2023

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HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta.
Alison Dickson, Eylan Yutuc, Catherine A Thornton, James E Dunford, Udo Oppermann, William J Griffiths

Open Biol· May 2023

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Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Kodihalli C Ravindra, Vishal S Vaidya, Zhenyu Wang, Joel D Federspiel, Richard Virgen-Slane, William J H Griffiths

Nat Commun· March 2023

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Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry.
Alison L Dickson, Eylan Yutuc, Catherine A Thornton, Yuqin Wang, William J Griffiths

Front Endocrinol (Lausanne)· November 2022

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Assessment of cholesterol homeostasis in the living human brain.
Achi Haider, Chunyu Zhao, Lu Wang, Zhiwei Xiao, Jian Rong, William J Griffiths

Sci Transl Med· October 2022

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Introducing the Lipidomics Minimal Reporting Checklist.
Jeffrey G McDonald, Christer S Ejsing, Dominik Kopczynski, Michal Holčapek, Junken Aoki, William J Griffiths

Nat Metab· September 2022

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Fazirsiran for Liver Disease Associated with Alpha-Antitrypsin Deficiency.
Pavel Strnad, Mattias Mandorfer, Gourab Choudhury, William Griffiths, Christian Trautwein

N Engl J Med· August 2022

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Reproducibility of Densitometric and Biomechanical Assessment of the Mouse Tibia From Micro-CT Images.
Sara Oliviero, Vee San Cheong, Bryant C Roberts, Carlos Amnael Orozco Diaz, William Griffiths

Front Endocrinol (Lausanne)· July 2022

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Investigation and management of Wilson's disease: a practical guide from the British Association for the Study of the Liver.
Samuel Shribman, Thomas Marjot, Abubakar Sharif, Sunitha Vimalesvaran, Aftab Ala, William Griffiths

Lancet Gastroenterol Hepatol· June 2022

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The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses.
Zack Saud, Victoria J Tyrrell, Andreas Zaragkoulias, Majd B Protty, Evelina Statkute, William J Griffiths

J Lipid Res· June 2022

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