Publications by authors named "Junken Aoki"

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LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex.
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Junken Aoki

iScience· January 2026

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Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions.
Yuki Ishino, Yuta Shimanaka, Junken Aoki, Nozomu Kono

Mol Omics· December 2025

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Spatial Mapping of PUFA Incorporation into Phospholipids with bisallylic deuteration.
Junji Obi, Kuniyuki Kano, Yuta Shimanaka, Shukichi Haisa, Nozomu Kono, Junken Aoki

J Lipid Res· December 2025

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Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils.
Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi, Yusuke Amiya, Junken Aoki

Alzheimers Res Ther· November 2025

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Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis.
Yutaro Saito, Mayuko Akita, Azusa Saika, Yusuke Sano, Masashi Hotta, Junken Aoki

Nat Chem· September 2025

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Solid-phase synthesis of polyunsaturated fatty acids facilitates precise structural investigation on FFAR1/4 agonist activities and the inhibition of neutrophil pseudopod formation.
Yaohong Shi, Yutaro Saito, Masashi Hotta, Mayuko Akita, Akiharu Uwamizu, Junken Aoki

RSC Adv· September 2025

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Discovery and development of an oral analgesic targeting the α2B adrenoceptor.
Masayasu Toyomoto, Takashi Kurihara, Takayuki Nakagawa, Asuka Inoue, Ryo Kimura, Junken Aoki

Proc Natl Acad Sci U S A· August 2025

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Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons.
Nicola Brandt, Arne Battefeld, Olga Suckau, Konstantin Stadler, Bhumika Singh, Junken Aoki

Cell Biosci· August 2025

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[Roles of Bioactive Lysophospholipids as Immunomodulators].
Junken Aoki

Yakugaku Zasshi· July 2025

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Hyperalgesia in the Psychological Stress-Induced Fibromyalgia Model Shows Sexual Dimorphism Mediated by LPA and LPA.
Hiroshi Ueda, Hiroyuki Neyama, Naoki Dozono, Junken Aoki, Jerold Chun

Cells· July 2025

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Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice.
Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Junken Aoki

Nat Commun· July 2025

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Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission.
Tomofumi Yoshida, Hiroyuki Kawano, Jumpei Omi, Tetsuya Hori, Yutaka Kobayashi, Junken Aoki

Cell Rep· May 2025

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Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation.
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, Kuniyuki Kano, Junken Aoki

iScience· May 2025

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Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state.
Keita Watanabe, Mayu Yamano, Junki Miyamoto, Ryuji Ohue-Kitano, Yuki Masujima, Junken Aoki

Cell Rep· March 2025

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Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.
Mary P Moore, Xiaobo Wang, John Paul Kennelly, Hongxue Shi, Yuki Ishino, Junken Aoki

Hepatology· February 2025

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Ligand-Independent Spontaneous Activation of Purinergic P2Y Receptor Under Cell Culture Soft Substrate.
Akiyuki Nishimura, Kazuhiro Nishiyama, Tomoya Ito, Xinya Mi, Yuri Kato, Junken Aoki

Cells· February 2025

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Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes.
Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Junken Aoki

FASEB Bioadv· October 2024

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Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.
Yoshitaka Taketomi, Takayoshi Higashi, Kuniyuki Kano, Yoshimi Miki, Chika Mochizuki, Junken Aoki

Immunity· August 2024

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New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line.
Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki

Tohoku J Exp Med· July 2024

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Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu.
Yoshinori Takano, Hiroshi Naraoka, Jason P Dworkin, Toshiki Koga, Kazunori Sasaki, Junken Aoki

Nat Commun· July 2024

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Visualization of Phospholipid Synthesis on Tissue Sections Using Functional Mass Spectrometry Imaging.
Taiga Iwama, Kuniyuki Kano, Hiroki Kawana, Hideo Shindou, Takao Shimizu, Junken Aoki

Anal Chem· July 2024

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Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate.
Masumi Oka, Sohta Akaki, Osamu Ohno, Maho Terasaki, Yuho Hamaoka-Tamura, Junken Aoki

J Pharmacol Exp Ther· March 2024

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Structural basis for lysophosphatidylserine recognition by GPR34.
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Junken Aoki

Nat Commun· February 2024

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Group III secreted phospholipase A -driven lysophospholipid pathway protects against allergic asthma.
Asako Hamu-Tanoue, Koichi Takagi, Yoshitaka Taketomi, Yoshimi Miki, Yasumasa Nishito, Junken Aoki

FASEB J· January 2024

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Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies.
Mazin A S Abdelwahid, Kosuke Ohsawa, Akiharu Uwamizu, Kuniyuki Kano, Junken Aoki

ACS Omega· December 2023

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