Publications by authors named "Bruce Jaffee"

Claim this Profile
C
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Maura A Crowley, Donita L Garland, Holger Sellner, Angela Banks, Lin Fan, Bruce D Jaffee

Hum Mol Genet· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of 4-((2,4)-4-Ethoxy-1-((5-methoxy-7-methyl-1-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Nello Mainolfi, Takeru Ehara, Rajeshri G Karki, Karen Anderson, Aengus Mac Sweeney, Bruce D Jaffee

J Med Chem· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Rajeshri G Karki, James Powers, Nello Mainolfi, Karen Anderson, David B Belanger, Bruce Jaffee

J Med Chem· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Anna Schubart, Karen Anderson, Nello Mainolfi, Holger Sellner, Takeru Ehara, Bruce Jaffee

Proc Natl Acad Sci U S A· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV).
Adrian Will-Orrego, Yubin Qiu, Elizabeth S Fassbender, Siyuan Shen, Jorge Aranda, Bruce D Jaffee

J Ocul Pharmacol Ther· September 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of .
Sha-Mei Liao, Wei Zheng, Jiang Zhu, Casey A Lewis, Omar Delgado, Bruce D Jaffee

Mol Vis· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Nonclinical Safety Evaluation of scAAV8- for Treatment of Retinitis Pigmentosa.
Timothy K MacLachlan, Mark N Milton, Oliver Turner, Francis Tukov, Vivian W Choi, Bruce D Jaffee

Mol Ther Methods Clin Dev· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
Christopher M Adams, Karen Anderson, Gerald Artman, Jean-Claude Bizec, Rosemarie Cepeda, Bruce Jaffee

J Med Chem· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models.
Maura A Crowley, Omar Delgado, Adrian Will-Orrego, Natasha M Buchanan, Karen Anderson, Bruce D Jaffee

Invest Ophthalmol Vis Sci· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Edwige Lorthiois, Karen Anderson, Anna Vulpetti, Olivier Rogel, Frederic Cumin, Bruce Jaffee

J Med Chem· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Long-acting protein drugs for the treatment of ocular diseases.
Joy G Ghosh, Andrew A Nguyen, Chad E Bigelow, Stephen Poor, Yubin Qiu, Bruce Jaffee

Nat Commun· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Jürgen Maibaum, Sha-Mei Liao, Anna Vulpetti, Nils Ostermann, Stefan Randl, Bruce Jaffee

Nat Chem Biol· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Lack of involvement of CEP adducts in TLR activation and in angiogenesis.
John Gounarides, Jennifer S Cobb, Jing Zhou, Frank Cook, Xuemei Yang, Bruce Jaffee

PLoS One· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.
Erik L Meredith, Nello Mainolfi, Stephen Poor, Yubin Qiu, Karl Miranda, Bruce Jaffee

J Med Chem· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.
Vivian W Choi, Chad E Bigelow, Terri L McGee, Akshata N Gujar, Hui Li, Bruce D Jaffee

Mol Ther Methods Clin Dev· July 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation.
Stephen H Poor, Yubin Qiu, Elizabeth S Fassbender, Siyuan Shen, Amber Woolfenden, Bruce D Jaffee

Invest Ophthalmol Vis Sci· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.
Nello Mainolfi, James Powers, Jakal Amin, Debby Long, Wendy Lee, Bruce Jaffee

J Med Chem· July 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization.
Jeremy M Sivak, Allison C Ostriker, Amber Woolfenden, John Demirs, Rosemarie Cepeda, Bruce Jaffee

J Biol Chem· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PCR primers with enhanced specificity for nematode-trapping fungi (Orbiliales).
Matthew E Smith, Bruce A Jaffee

Microb Ecol· July 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.
Geraldine C Harriman, Matthias Brewer, Robert Bennett, Cyrille Kuhn, Marc Bazin, Bruce Jaffee

Bioorg Med Chem Lett· April 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Florian R Greten, Melek C Arkan, Julia Bollrath, Li-Chung Hsu, Jason Goode, Bruce B Jaffee

Cell· September 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quantitation of peripheral blood markers of rat experimental autoimmune encephalomyelitis.
Elena Izmailova, Russell Walker, Michael Fitzgerald, Timothy Ocain, Bruce Jaffee

Autoimmunity· July 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Response of nematode-trapping fungi to organic substrates in a coastal grassland soil.
Vi L Nguyen, Justin L Bastow, Bruce A Jaffee, Don R Strong

Mycol Res· July 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Small molecule antagonists of the CC chemokine receptor 4 (CCR4).
Douglas F Burdi, Shannon Chi, Karen Mattia, Celeste Harrington, Zhan Shi, Bruce Jaffee

Bioorg Med Chem Lett· June 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Elena S Izmailova, Nancy Paz, Herlen Alencar, Miyoung Chun, Lisa Schopf, Bruce Jaffee

Arthritis Rheum· January 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis