Publications by authors named "Timothy Ocain"

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Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma.
Lin Wang, Tracy J Jenkins, Mingshi Dai, Wei Yin, Jacqueline C Pulido, Timothy Ocain

Thorax· June 2013

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Fragile X syndrome: an update on developing treatment modalities.
Aileen Healy, Roger Rush, Timothy Ocain

ACS Chem Neurosci· August 2011

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Mechanism-based approaches to treating fragile X.
Gül Dölen, Randall L Carpenter, Timothy D Ocain, Mark F Bear

Pharmacol Ther· July 2010

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Florian R Greten, Melek C Arkan, Julia Bollrath, Li-Chung Hsu, Jason Goode

Cell· September 2007

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Quantitation of peripheral blood markers of rat experimental autoimmune encephalomyelitis.
Elena Izmailova, Russell Walker, Michael Fitzgerald, Timothy Ocain, Bruce Jaffee

Autoimmunity· July 2007

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Small molecule antagonists of the CC chemokine receptor 4 (CCR4).
Douglas F Burdi, Shannon Chi, Karen Mattia, Celeste Harrington, Zhan Shi, Timothy Ocain

Bioorg Med Chem Lett· June 2007

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Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.
Tracy J Jenkins, Bing Guan, Mingshi Dai, Gang Li, Thomas E Lightburn, Timothy D Ocain

J Med Chem· February 2007

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Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.
Hong Cheng, Terri Addona, Hasmik Keshishian, Erik Dahlstrand, Chafen Lu, Timothy D Ocain

Biochem Biophys Res Commun· January 2007

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Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Elena S Izmailova, Nancy Paz, Herlen Alencar, Miyoung Chun, Lisa Schopf, Timothy Ocain

Arthritis Rheum· January 2007

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IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
Lisa Schopf, Anneli Savinainen, Karen Anderson, Julie Kujawa, Michelle DuPont, Timothy Ocain

Arthritis Rheum· October 2006

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A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.
Danyi Wen, Yuhua Nong, Jennifer G Morgan, Pranoti Gangurde, Andrew Bielecki, Timothy D Ocain

J Pharmacol Exp Ther· June 2006

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Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.
Chafen Lu, Anlai Wang, Lin Wang, Marion Dorsch, Timothy D Ocain

Biochem Biophys Res Commun· June 2005

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Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2).
Fang Liu, Jose Angel Gonzalo, Stephen Manning, Laura E O'Connell, Eric R Fedyk, Timothy D Ocain

Prostaglandins Other Lipid Mediat· May 2005

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Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity.
Chafen Lu, Anlai Wang, Marion Dorsch, Jane Tian, Kumiko Nagashima, Timothy D Ocain

J Biol Chem· April 2005

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Novel small-molecule inhibitors of RNA polymerase III.
Liping Wu, Jing Pan, Vala Thoroddsen, Deborah R Wysong, Ronald K Blackman, Timothy D Ocain

Eukaryot Cell· April 2003

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Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.
Natalie A Dales, Alexandra E Gould, James A Brown, Emily F Calderwood, Bing Guan, Timothy D Ocain

J Am Chem Soc· October 2002

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