Publications by authors named "Bumsang Shim"

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miR-193a-5p-mediated Inhibition of the METTL1/COX-2 axis is critical for Astragalin-induced apoptosis in cervical cancer.
Yuchan Lee, Su-Yeon Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim

Sci Rep· December 2025

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STK32C as a Therapeutic Target in Colorectal Cancer via HSP90-PI3K/AKT/mTOR Signaling.
Chi-Hoon Ahn, Ji Eon Park, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim

Int J Biol Sci· November 2025

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ZBTB7B modulates the androgen receptor as an upstream regulator via colocalization and direct binding in LNCaP prostate cancer cells.
Eunji Im, Su-Yeon Park, Deok-Yong Sim, Ah Reum Cho, Bum Ju Kil, Bum-Sang Shim

Transl Cancer Res· November 2025

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Inhibition of LGR5/β-Catenin Axis and Activation of miR134 Are Critically Involved in Apoptotic Effect of Sanggenol L in Hepatocellular Carcinoma.
Jisung Hwang, Deok Yong Sim, Chi-Hoon Ahn, Su-Yeon Park, Jin-Suk Koo, Bum-Sang Shim

Biol Pharm Bull· May 2025

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Crucial Role of c-Myc/Monocarboxylate Transporter 4 Signaling in Capsaicin Induced Apoptotic and Anti-Warburg Effects in Hepatocellular Carcinoma.
Jin Young Suh, Deok Yong Sim, Chi-Hoon Ahn, Su-Yeon Park, Bum-Sang Shim

Phytother Res· January 2025

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Anti-Warburg Mechanism of Ginsenoside F2 in Human Cervical Cancer Cells via Activation of miR193a-5p and Inhibition of β-Catenin/c-Myc/Hexokinase 2 Signaling Axis.
Nari Shin, Hyo-Jung Lee, Deok Yong Sim, Chi-Hoon Ahn, Su-Yeon Park, Bum-Sang Shim

Int J Mol Sci· August 2024

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Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy.
Deok Yong Sim, Hyo-Jung Lee, Chi-Hoon Ahn, JiEon Park, Su-Yeon Park, Bum-Sang Shim

Int J Biol Sci· July 2024

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Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.
Youngsang Park, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Bum-Sang Shim

Phytother Res· March 2024

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The microRNA-193a-5p induced ROS production and disturbed colocalization between STAT3 and androgen receptor play critical roles in cornin induced apoptosis.
Jhin-Baek Choi, Deok Yong Sim, Hyo-Jung Lee, Ji Eon Park, Chi-Hoon Ahn, Bum-Sang Shim

Phytother Res· February 2024

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Extract Induces Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Heat Shock Protein 27 and Androgen Receptor in Prostate Cancers.
Seok-Young Kim, Ji Eon Park, Hyo-Jung Lee, Deok Yong Sim, Chi-Hoon Ahn, Bum-Sang Shim

Int J Mol Sci· February 2024

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Apoptotic and anti-Warburg effect of Morusin via ROS mediated inhibition of FOXM1/c-Myc signaling in prostate cancer cells.
Ja Il Koo, Deok Yong Sim, Hyo-Jung Lee, Chi-Hoon Ahn, JiEon Park, Bum-Sang Shim

Phytother Res· October 2023

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Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells.
Ji-Na Pak, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Bumsang Shim

Phytother Res· September 2023

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The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis.
Hyeon Hee Kwon, Chi-Hoon Ahn, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Bum-Sang Shim

Int J Mol Sci· September 2023

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The underlying hepatoprotective mechanism of PKC#963 in alcohol or carbon tetrachloride induced liver injury via inhibition of iNOS, COX-2, and p-STAT3 and enhancement of SOD and catalase.
Dong Sub Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Youngsang Park, Bumsang Shim

Phytother Res· February 2023

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Leonurus japonicus Houttuyn induces reactive oxygen species-mediated apoptosis via regulation of miR-19a-3p/PTEN/PI3K/AKT in U937 and THP-1 cells.
Moon Nyeo Park, Eun-Sik Um, Md Ataur Rahman, Jeong Woo Kim, Se Sun Park, Bum-Sang Shim

J Ethnopharmacol· June 2022

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BK002 Induces miR-192-5p-Mediated Apoptosis in Castration-Resistant Prostate Cancer Cells Modulation of PI3K/CHOP.
Moon Nyeo Park, Hyunmin Park, Md Ataur Rahman, Jeong Woo Kim, Se Sun Park, Bum-Sang Shim

Front Oncol· March 2022

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UBE2M Drives Hepatocellular Cancer Progression as a p53 Negative Regulator by Binding to MDM2 and Ribosomal Protein L11.
Ju-Ha Kim, Ji Hoon Jung, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Bum-Sang Shim

Cancers (Basel)· September 2021

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Antitumor Effect of Morusin via G1 Arrest and Antiglycolysis by AMPK Activation in Hepatocellular Cancer.
Ah-Reum Cho, Woon-Yi Park, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Bum-Sang Shim

Int J Mol Sci· September 2021

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The Natural Products Targeting on Allergic Rhinitis: From Traditional Medicine to Modern Drug Discovery.
Suhyun Lim, Iwah Jeong, Jonghyeok Cho, Chaewon Shin, Kwan-Il Kim, Bum-Sang Shim

Antioxidants (Basel)· September 2021

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miR193a-5p Mediated ZNF746 and c-Myc Signaling Axis Is Critically Involved in Morusin Induced Apoptosis in Colorectal Cancer Cells.
Woon-Yi Park, Hyo-Jung Lee, Deok-Yong Sim, Eunji Im, Ji-Eon Park, Bum-Sang Shim

Cells· August 2021

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Inhibition of STAT3/PD-L1 and Activation of miR193a-5p Are Critically Involved in Apoptotic Effect of Compound K in Prostate Cancer Cells.
Jae-Hee Lee, Dae-Young Lee, Hyo-Jung Lee, Eunji Im, Deok-Yong Sim, Bum-Sang Shim

Cells· August 2021

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Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression.
Bonglee Kim, Ji-Eon Park, Eunji Im, Yongmin Cho, Jinjoo Lee, Bum-Sang Shim

Int J Mol Sci· March 2021

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Phyotochemical candidates repurposing for cancer therapy and their molecular mechanisms.
Ji Hoon Jung, Jisung Hwang, Ju-Ha Kim, Deok Yong Sim, Eunji Im, Bum-Sang Shim

Semin Cancer Biol· January 2021

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p53 dependent LGR5 inhibition and caspase 3 activation are critically involved in apoptotic effect of compound K and its combination therapy potential in HCT116 cells.
Ji-Na Pak, Ji Hoon Jung, Ji Eon Park, Jisung Hwang, Hyo Jung Lee, Bum-Sang Shim

Phytother Res· October 2020

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Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine.
Hyeonjin Jeon, Wankyu Eo, Bumsang Shim, Sehyun Kim, Sookyung Lee

Evid Based Complement Alternat Med· January 2020

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