Publications by authors named "Caitlin Shepard"

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Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Caitlin Shepard

mBio· September 2024

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Elimination of Aicardi-Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
Adrian Oo, Keivan Zandi, Caitlin Shepard, Leda C Bassit, Katie Musall

J Biol Chem· March 2022

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MESH1 knockdown triggers proliferation arrest through TAZ repression.
Tianai Sun, Chien-Kuang Cornelia Ding, Yuning Zhang, Yang Zhang, Chao-Chieh Lin, Caitlin Shepard

Cell Death Dis· March 2022

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SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
BradleyS Barrett, David H Nguyen, Joella Xu, Kejun Guo, Shravida Shetty, Caitlin Shepard

J Immunol· January 2022

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Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Nicole E Bowen, Joshua Temple, Caitlin Shepard, Adrian Oo, Fidel Arizaga

J Biol Chem· October 2021

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Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
Jihane Basbous, Antoine Aze, Laurent Chaloin, Rana Lebdy, Dana Hodroj, Caitlin Shepard

Nucleic Acids Res· February 2020

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Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages.
Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M Mansky

Retrovirology· October 2019

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Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.
Zhonghua Wang, Akash Bhattacharya, Tommy White, Cindy Buffone, Aine McCabe, Caitlin N Shepard

Cell Rep· July 2018

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Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.
Kerstin Schott, Nina V Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Caitlin Shepard

Nat Commun· June 2018

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SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Eddy Sanchai Thientosapol, Daniel Bosnjak, Timothy Durack, Igor Stevanovski, Michelle van Geldermalsen, Caitlin Shepard

Proc Natl Acad Sci U S A· May 2018

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A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
Corine St Gelais, Sun Hee Kim, Victoria V Maksimova, Olga Buzovetsky, Kirsten M Knecht, Caitlin Shepard

J Virol· March 2018

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The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N Shepard, Baek Kim

Mob DNA· March 2018

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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Waaqo Daddacha, Allyson E Koyen, Amanda J Bastien, PamelaSara E Head, Vishal R Dhere, Caitlin Shepard

Cell Rep· August 2017

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The small-molecule 3G11 inhibits HIV-1 reverse transcription.
Silvana Opp, Thomas Fricke, Caitlin Shepard, Dmytro Kovalskyy, Akash Bhattacharya

Chem Biol Drug Des· April 2017

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A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Nicolin Bloch, Sabine Gläsker, Poojitha Sitaram, Henning Hofmann, Caitlin N Shepard

J Biol Chem· January 2017

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HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes.
Daniel C Anacker, Heather L Aloor, Caitlin N Shepard, Gina M Lenzi, Bryan A Johnson

Virology· December 2016

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SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.
Jenna M Antonucci, Corine St Gelais, Suresh de Silva, Jacob S Yount, Chenxiang Tang, Caitlin Shepard

Nat Med· October 2016

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SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.
Serena Bonifati, Michele B Daly, Corine St Gelais, Sun Hee Kim, Joseph A Hollenbaugh, Caitlin Shepard

Virology· August 2016

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Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.
Akash Bhattacharya, Zhonghua Wang, Tommy White, Cindy Buffone, Laura A Nguyen, Caitlin N Shepard

Sci Rep· August 2016

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Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Andreas F R Sommer, Lise Rivière, Bingqian Qu, Kerstin Schott, Maximilian Riess, Caitlin Shepard

Sci Rep· May 2016

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Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.
Feifei Wang, Corine St Gelais, Suresh de Silva, Hong Zhang, Yu Geng, Caitlin Shepard

Virology· January 2016

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An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.
Annelies Stevaert, Salvatore Nurra, Nicolino Pala, Mauro Carcelli, Dominga Rogolino, Caitlin Shepard

Mol Pharmacol· February 2015

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