Publications by authors named "Carla Scali"

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New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia.
Alan Zanardi, Ilaria Nardini, Sara Raia, Antonio Conti, Barbara Ferrini, Carla Scali

Commun Biol· January 2024

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Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity.
Cristina Meregalli, Laura Monza, Alessia Chiorazzi, Carla Scali, Chiara Guarnieri

Int J Mol Sci· January 2021

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High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats.
Cristina Meregalli, Ivan Marjanovic, Carla Scali, Laura Monza, Nadia Spinoni

J Neuroinflammation· August 2018

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Multimodal molecular imaging system for pathway-specific reporter gene expression.
Marco Rossi, Luisa Massai, Daniela Diamanti, Pasquale Fiengo, Antonella De Rosa, Carla Scali

Eur J Pharm Sci· April 2016

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Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.
Ilaria Ceccarelli, Pasquale Fiengo, Rosaria Remelli, Vincenzo Miragliotta, Lara Rossini, Carla Scali

Neurobiol Dis· February 2016

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siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Carla Scali

Nat Chem Biol· May 2015

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A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Marianne R Smith, Adeela Syed, Tamas Lukacsovich, Judy Purcell, Brett A Barbaro, Carla Scali

Hum Mol Genet· June 2014

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Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity.
Salvatore La Rosa, Tiziana Benicchi, Laura Bettinetti, Ilaria Ceccarelli, Enrica Diodato, Carla Scali

ACS Med Chem Lett· October 2013

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N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
Riccardo Zanaletti, Laura Bettinetti, Cristiana Castaldo, Ilaria Ceccarelli, Giuseppe Cocconcelli, Carla Scali

J Med Chem· November 2012

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Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
Riccardo Zanaletti, Laura Bettinetti, Cristiana Castaldo, Giuseppe Cocconcelli, Thomas Comery, Carla Scali

J Med Chem· May 2012

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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
Karen L Marquis, Thomas A Comery, Flora Jow, Rachel L Navarra, Steven M Grauer, Carla Scali

Psychopharmacology (Berl)· December 2011

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VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
Lara Rossini, Yuichi Hashimoto, Hiroaki Suzuki, Megumi Kurita, Marco Gianfriddo, Carla Scali

FASEB J· June 2011

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Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
Chiara Ghiron, Simon N Haydar, Suzan Aschmies, Hendrick Bothmann, Cristiana Castaldo, Carla Scali

J Med Chem· June 2010

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Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.
Maria Cristina Rosi, Ilaria Luccarini, Cristina Grossi, Anna Fiorentini, Maria Grazia Spillantini, Carla Scali

J Neurochem· March 2010

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SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.
Simon N Haydar, Chiara Ghiron, Laura Bettinetti, Hendrick Bothmann, Thomas A Comery, Carla Scali

Bioorg Med Chem· July 2009

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Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
Renza Roncarati, Carla Scali, Thomas A Comery, Steven M Grauer, Suzan Aschmi

J Pharmacol Exp Ther· May 2009

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Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Carla Scali, Filippo Caraci, Marco Gianfriddo, Enrica Diodato, Renza Roncarati

Neurobiol Dis· November 2006

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Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice.
Arianna Bellucci, Ilaria Luccarini, Carla Scali, Costanza Prosperi, Maria Grazia Giovannini

Neurobiol Dis· August 2006

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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali

Proc Natl Acad Sci U S A· November 2005

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Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.
Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi

Neurobiol Dis· November 2002

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Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease.
Carla Scali, Costanza Prosperi, Laura Bracco, Carolina Piccini, Roberto Baronti

Neurobiol Aging· July 2002

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