Publications by authors named "Carleigh A O'Brien"

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Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice.
Samuelle A S Delcy, Anthony Farrugia, Ian A Diaz Nieves, Carleigh A O'Brien, Frederick C Bennett

Brain Behav Immun· January 2026

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Neonatal microglia replacement in mice modulates seizure severity in adulthood.
Carleigh A O'Brien, Samuelle A S Delcy, Sangeeta Shukla, Eli M Levitt, Akiva S Cohen

Mol Ther· December 2025

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Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells.
Sonia I Lombroso, Emily I Church, Ryan N Anderson, Carleigh A O'Brien, Yixuan Zhu

Mol Ther· November 2025

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Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology.
Kelsey M Nemec, Genevieve Uy, V Sai Chaluvadi, Freddy S Purnell, Bilal Elfayoumi, Carleigh A O'Brien

bioRxiv· May 2025

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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.
William H Aisenberg, Carleigh A O'Brien, Madison Sangster, Fazeela Yaqoob, Yuanchao Zhang

Immunity· May 2025

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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
Caterina P Profaci, Sean S Harvey, Kaja Bajc, Tony Z Zhang, Danielle A Jeffrey, Carleigh A O'Brien

Neuron· September 2024

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Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.
Jean Paul Chadarevian, Sonia I Lombroso, Graham C Peet, Jonathan Hasselmann, Christina Tu, Carleigh A O'Brien

J Exp Med· March 2023

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Perivascular signals drive microglial appetite.
Carleigh A O'Brien, F Chris Bennett

Nat Neurosci· March 2023

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Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
Maureen N Cowan, Michael A Kovacs, Ish Sethi, Isaac W Babcock, Katherine Still, Carleigh A O'Brien

PLoS Pathog· September 2022

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Microglia in antiviral immunity of the brain and spinal cord.
Carleigh A O'Brien, F Chris Bennett, Mariko L Bennett

Semin Immunol· March 2022

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Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
Katherine M Still, Samantha J Batista, Carleigh A O'Brien, Oyebola O Oyesola, Simon P Früh

PLoS Pathog· October 2020

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ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.
Carleigh A O'Brien, Tajie H Harris

PLoS One· April 2020

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IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Infection.
Carleigh A O'Brien, Samantha J Batista, Katherine M Still, Tajie H Harris

J Immunol· March 2019

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CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.
Carleigh A O'Brien, Christopher Overall, Christoph Konradt, Aisling C O'Hara Hall, Nikolas W Hayes

J Immunol· May 2017

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