Publications by authors named "Michael A Kovacs"

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Caspase-8 expression in CD8 T cells promotes pathogen restriction in the brain during infection.
Lydia A Sibley, Maureen N Cowan, Abigail G Kelly, NaaDedee A Amadi, Isaac W Babcock, Michael A Kovacs

Sci Adv· December 2025

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Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection.
Isaac W Babcock, Lydia A Sibley, Sydney A Labuzan, Maureen N Cowan, Ish Sethi, Michael A Kovacs

PLoS Pathog· October 2024

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Vascular Endothelial Growth Factor-C Treatment Enhances Cerebrospinal Fluid Outflow during Toxoplasma gondii Brain Infection but Does Not Improve Cerebral Edema.
Michael A Kovacs, Isaac W Babcock, Ana Royo Marco, Lydia A Sibley, Abigail G Kelly

Am J Pathol· February 2024

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The meningeal transcriptional response to traumatic brain injury and aging.
Ashley C Bolte, Daniel A Shapiro, Arun B Dutta, Wei Feng Ma, Katherine R Bruch, Michael A Kovacs

Elife· January 2023

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Meningeal lymphatic drainage promotes T cell responses against but is dispensable for parasite control in the brain.
Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still

Elife· December 2022

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Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
Maureen N Cowan, Michael A Kovacs, Ish Sethi, Isaac W Babcock, Katherine Still

PLoS Pathog· September 2022

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Investigating the genetic architecture of eye colour in a Canadian cohort.
Frida Lona-Durazo, Rohit Thakur, Erola Pairo-Castineira, Karen Funderburk, Tongwu Zhang, Michael A Kovacs

iScience· June 2022

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A large Canadian cohort provides insights into the genetic architecture of human hair colour.
Frida Lona-Durazo, Marla Mendes, Rohit Thakur, Karen Funderburk, Tongwu Zhang, Michael A Kovacs

Commun Biol· November 2021

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Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms.
Tongwu Zhang, Jiyeon Choi, Ramile Dilshat, Berglind Ósk Einarsdóttir, Michael A Kovacs

Am J Hum Genet· September 2021

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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.
Mai Xu, Lindsey Mehl, Tongwu Zhang, Rohit Thakur, Hayley Sowards, Michael A Kovacs

Am J Hum Genet· September 2021

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Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
Katherine M Still, Samantha J Batista, Carleigh A O'Brien, Oyebola O Oyesola, Simon P Früh, Michael A Kovacs

PLoS Pathog· October 2020

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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
Ashley C Bolte, Arun B Dutta, Mariah E Hurt, Igor Smirnov, Michael A Kovacs

Nat Commun· September 2020

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Long-'Trm' protection of the CNS.
Michael A Kovacs, Tajie H Harris

Nat Immunol· August 2020

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Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M Makowski, Michael A Kovacs

Nat Commun· June 2020

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Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations.
Frida Lona-Durazo, Natalia Hernandez-Pacheco, Shaohua Fan, Tongwu Zhang, Jiyeon Choi, Michael A Kovacs

BMC Genet· July 2019

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Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.
Tongwu Zhang, Jiyeon Choi, Michael A Kovacs, Jianxin Shi, Mai Xu

Genome Res· November 2018

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A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF.
Jiyeon Choi, Mai Xu, Matthew M Makowski, Tongwu Zhang, Matthew H Law, Michael A Kovacs

Nat Genet· September 2017

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