Publications by authors named "Caroline Low"

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The rise of AlphaFold in drug design.
Adrian Stecula, Rebecca Paul, Kevin Litchfield, Samuel E Dalton, Caroline M R Low

Prog Med Chem· October 2025

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Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3.
Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Caroline M R Low

Nature· December 2024

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Accurate structure prediction of biomolecular interactions with AlphaFold 3.
Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Caroline M R Low

Nature· June 2024

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Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer, therapeutic treatment options for platinum-resistant ovarian cancer.
Natasha Rinne, Elizabeth L Christie, Anastasia Ardasheva, Chun Hei Kwok, Nikita Demchenko, Caroline Low

Cancer Drug Resist· April 2021

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Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors.
Sandra Sacre, Albert Jaxa-Chamiec, Caroline M R Low, Giselle Chamberlain, Cathy Tralau-Stewart

Front Immunol· August 2020

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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Caroline M R Low

Cell Stem Cell· March 2020

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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Caroline M R Low

Cell Stem Cell· April 2019

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Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors.
Heba Alshaker, Shyam Srivats, Danielle Monteil, Qi Wang, Caroline M R Low

Breast Cancer Res Treat· November 2018

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The development of novel LTAH modulators to selectively target LTB generation.
Caroline M Low, Samia Akthar, Dhiren F Patel, Stephan Löser, Chi-Tung Wong

Sci Rep· March 2017

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Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors.
Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci

Cancer Cell· December 2014

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Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.
Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci

Cancer Cell· October 2014

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UK academic drug discovery.
Cathy Tralau-Stewart, Caroline M R Low, Nicola Marlin

Nat Rev Drug Discov· January 2014

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Interplay of self-association and solvation in polar liquids.
Valeria Amenta, Joanne L Cook, Christopher A Hunter, Caroline M R Low, Hongmei Sun

J Am Chem Soc· August 2013

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Influence of solvent polarity on preferential solvation of molecular recognition probes in solvent mixtures.
Valeria Amenta, Joanne L Cook, Christopher A Hunter, Caroline M R Low, Jeremy G Vinter

J Phys Chem B· December 2012

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Molecular recognition probes of solvation thermodynamics in solvent mixtures.
Valeria Amenta, Joanne L Cook, Christopher A Hunter, Caroline M R Low, Jeremy G Vinter

Org Biomol Chem· November 2011

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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm.
Kotaro Shide, Takuro Kameda, Vadim Markovtsov, Haruko K Shimoda, Elizabeth Tonkin, Caroline Low

Blood· June 2011

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Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
John McLaughlin, Vadim Markovtsov, Hui Li, Steve Wong, Marina Gelman, Caroline Low

J Cancer Res Clin Oncol· January 2010

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Linking non-peptide ligand binding mode to activity at the human cholecystokinin-2 receptor.
Magali Foucaud, Esther Marco, Chantal Escrieut, Caroline Low, Barret Kalindjian

J Biol Chem· December 2008

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Preferential solvation and hydrogen bonding in mixed solvents.
Joanne L Cook, Christopher A Hunter, Caroline M R Low, Alejandro Perez-Velasco, Jeremy G Vinter

Angew Chem Int Ed Engl· September 2008

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Rationalizing the activities of diverse cholecystokinin 2 receptor antagonists using molecular field points.
Caroline M R Low, J G Vinter

J Med Chem· February 2008

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Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.
Iain M McDonald, Carol Austin, Ildiko M Buck, David J Dunstone, John Gaffen, Caroline M R Low

J Med Chem· October 2007

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Solvent effects on hydrogen bonding.
Joanne L Cook, Christopher A Hunter, Caroline M R Low, Alejandro Perez-Velasco, Jeremy G Vinter

Angew Chem Int Ed Engl· August 2007

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Substituent effects on aromatic stacking interactions.
Scott L Cockroft, Julie Perkins, Cristiano Zonta, Harry Adams, Sharon E Spey, Caroline M R Low

Org Biomol Chem· April 2007

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Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.
Iain M McDonald, Carol Austin, Ildiko M Buck, David J Dunstone, Eric Griffin, Caroline M R Low

J Med Chem· April 2006

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Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Ildiko M Buck, James W Black, Tracey Cooke, David J Dunstone, John D Gaffen, Caroline M R Low

J Med Chem· November 2005

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