Publications by authors named "Cecil Chen"

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Safety, Tolerability, and Pharmacokinetics of the Long-Acting SARS-CoV-2-Neutralizing Monoclonal Antibody Combination AZD7442 (Tixagevimab/Cilgavimab) in Healthy Chinese Adults.
Nanyang Li, Jing Zhang, Wenhong Zhang, Zhongyuan Xu, Xiangcao Yao, Cecil Chi-Keung Chen

Clin Pharmacol Drug Dev· November 2025

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Safety and Pharmacokinetics of Long-Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect.
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Cecil Chi-Keung Chen

Clin Pharmacol Drug Dev· November 2025

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Clinical evidence of immunogenicity of CAR-T cell therapies and its implication in the clinical development of CAR-T drug products.
Hammodah R Alfar, Cecil Chen, Eric Lachacz, Weifeng Tang, Yuqian Zhang

Front Immunol· May 2025

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2024 White Paper on Recent Issues in Bioanalysis: Evolution of Immunogenicity Assessment beyond ADA/NAb; Regulated Genomic/NGS Assays; Hypersensitivity Reactions; Minimum Noise Reduction; False Positive Range; Modernized Vaccine Approaches; NAb/TAb Correlation - Recommendations on Advanced Strategies for Molecular Assays and Immunogenicity of Gene Therapy, Cell Therapy, Vaccine; Biotherapeutics Immunogenicity Assessment & Clinical Relevance - Regulatory Agencies' Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell & Vaccine Therapies).
Omar Tounekti, Sandra Prior, Sarah Wassmer, Joshua Xu, Adrian Wong, Cecil Chen

Bioanalysis· February 2025

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Population pharmacokinetics and exposure-response analysis of durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer.
Aburough Abegesah, Do-Youn Oh, KyoungSoo Lim, Chunling Fan, Cecil Chen

Cancer Chemother Pharmacol· January 2025

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Population Pharmacokinetics and Exposure-Response Analysis for the CTLA-4 Inhibitor Tremelimumab in Metastatic NSCLC Patients in the Phase III POSEIDON Study.
Jimmy Zhijian He, Vincent Duval, Petra Jauslin, Antonio Gonçalves, Aburough Abegesah, Cecil Chen

Clin Pharmacol Ther· December 2023

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Population Pharmacokinetics and Exposure-Response Analysis of Tremelimumab 300 mg Single Dose Combined with Durvalumab 1500 mg Q4W (STRIDE) in Patients with Unresectable Hepatocellular Carcinoma.
KyoungSoo Lim, Aburough Abegesah, Chunling Fan, Jimmy Zhijian He, Xuyang Song, Cecil Chen

J Clin Pharmacol· November 2023

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Safety, tolerability, and pharmacokinetics of half-life extended SARS-CoV-2-neutralizing monoclonal antibodies AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.
Hiroshi Okada, Kensuke Ishikawa, Yohji Itoh, Yoshinori Noda, Takashi Eto, Cecil Chi-Keung Chen

J Infect Chemother· November 2023

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Population pharmacokinetic modelling of tremelimumab in patients with advanced solid tumours and the impact of disease status on time-varying clearance.
Michael Hwang, Yen Lin Chia, Yanan Zheng, Cecil Chi-Keung Chen, Jimmy He

Br J Clin Pharmacol· May 2023

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Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab) in Healthy Adults.
Pablo Forte-Soto, Muna Albayaty, Dennis Brooks, Rosalinda H Arends, John Tillinghast, Cecil Chen

J Infect Dis· May 2023

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Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants.
Tommy Tsang Cheung, Tu H Mai, Yen Lin Chia, Desmond Y H Yap, Chi-Ho Lee, Cecil Chi-Keung Chen

Drug Des Devel Ther· February 2023

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A new method for identification of outliers in immunogenicity assay cut point data.
Jianchun Zhang, Rosalin Hgp Arends, Robert J Kubiak, Lorin K Roskos, Meina Liang, Cecil Chi-Keung Chen

J Immunol Methods· March 2021

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Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy.
Padmanee Sharma, Joohyuk Sohn, Sang Joon Shin, Do-Youn Oh, Bhumsuk Keam, Cecil Chi-Keung Chen

Clin Cancer Res· January 2020

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Selection of a Ligand-Binding Neutralizing Antibody Assay for Benralizumab: Comparison with an Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Cell-Based Assay.
Yuling Wu, Ahmad Akhgar, Jia J Li, Binbing Yu, Cecil Chen

AAPS J· March 2018

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Association between leukocyte telomere length and vascular dementia and cancer mortality in an elderly population.
Cecil Chen, Ciaran Upton, Nady Braidy, Jinan Khalil, Zhi-Ming Fang

J Am Geriatr Soc· July 2014

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Bioavailability, Pharmacokinetics, and Safety of Belimumab Administered Subcutaneously in Healthy Subjects.
Wendy W Cai, Michele Fiscella, Cecil Chen, Z John Zhong, William W Freimuth

Clin Pharmacol Drug Dev· October 2013

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Population pharmacokinetics of belimumab following intravenous administration in patients with systemic lupus erythematosus.
Herbert Struemper, Cecil Chen, Wendy Cai

J Clin Pharmacol· July 2013

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Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits.
Alfred Corey, Thi-Sau Migone, Sally Bolmer, Michele Fiscella, Chris Ward, Cecil Chen

Toxins (Basel)· January 2013

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Population pharmacokinetics and exposure-response of albinterferon alfa-2b.
Matthew M Riggs, Timothy T Bergsma, James A Rogers, Marc R Gastonguay, G Mani Subramanian, Cecil Chen

J Clin Pharmacol· April 2012

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Does the burning of moxa (Artemisia vulgaris) in traditional Chinese medicine constitute a health hazard?
John Wheeler, Belinda Coppock, Cecil Chen

Acupunct Med· March 2009

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Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients.
Jacob Lalezari, Gopal K Yadavalli, Michael Para, Gary Richmond, Edwin Dejesus, Cecil Chen

J Infect Dis· March 2008

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Crystal structure of BMP-9 and functional interactions with pro-region and receptors.
Monica A Brown, Qinghai Zhao, Kent A Baker, Chethana Naik, Cecil Chen

J Biol Chem· July 2005

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Development of a long-acting insulin analog using albumin fusion technology.
Alokesh Duttaroy, Palanisamy Kanakaraj, Blaire L Osborn, Helmut Schneider, Oxana K Pickeral, Cecil Chen, Susan Cheng

Diabetes· January 2005

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An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis.
Cecil Chen, Krzysztof J Grzegorzewski, Steve Barash, Qinghai Zhao, Helmut Schneider, Susan Cheng

Nat Biotechnol· March 2003

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TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model.
Michele Fiscella, James W Perry, Baiqin Teng, Michael Bloom, Chen Zhang, Cecil Chen, Guoxian Chen

Nat Biotechnol· March 2003

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