Publications by authors named "Cedric Shackleton"

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Steroids and Mass Spectrometry: A Personal Story.
Cedric H L Shackleton

J Steroid Biochem Mol Biol· January 2025

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Urine steroid metabolomics as a diagnostic tool in primary aldosteronism.
Alessandro Prete, Katharina Lang, David Pavlov, Yara Rhayem, Alice J Sitch, Cedric H L Shackleton

J Steroid Biochem Mol Biol· March 2024

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The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series.
Min Sun, Jonathan W Mueller, Lorna C Gilligan, Angela E Taylor, Fozia Shaheen, Cedric H L Shackleton

Eur J Endocrinol· October 2021

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Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates.
Jonas Abdel-Khalik, Thomas Hearn, Alison L Dickson, Peter J Crick, Eylan Yutuc, Cedric H Shackleton

J Steroid Biochem Mol Biol· February 2021

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Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study.
Irina Bancos, Angela E Taylor, Vasileios Chortis, Alice J Sitch, Carl Jenkinson, Cedric H L Shackleton

Lancet Diabetes Endocrinol· September 2020

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Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency.
Nicole Reisch, Richard J Auchus, Cedric H L Shackleton, Neil A Hanley, Wiebke Arlt

Proc Natl Acad Sci U S A· June 2020

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Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism.
Karl-Heinz Storbeck, Lina Schiffer, Elizabeth S Baranowski, Vasileios Chortis, Alessandro Prete, Cedric H L Shackleton

Endocr Rev· December 2019

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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.
Lina Schiffer, Lise Barnard, Elizabeth S Baranowski, Lorna C Gilligan, Angela E Taylor, Cedric H L Shackleton

J Steroid Biochem Mol Biol· November 2019

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Alternative pathway androgen biosynthesis and human fetal female virilization.
Nicole Reisch, Angela E Taylor, Edson F Nogueira, Daniel J Asby, Vivek Dhir, Cedric H L Shackleton

Proc Natl Acad Sci U S A· October 2019

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Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study.
Rachel K Crowley, Conor P Woods, Beverly A Hughes, Joanna Gray, Theresa McCarthy, Cedric H L Shackleton

Clin Endocrinol (Oxf)· July 2019

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SULFATION PATHWAYS: Alternate steroid sulfation pathways targeted by LC-MS/MS analysis of disulfates: application to prenatal diagnosis of steroid synthesis disorders.
Oscar J Pozo, Josep Marcos, Olha Khymenets, Andy Pranata, Christopher C Fitzgerald, Cedric Shackleton

J Mol Endocrinol· August 2018

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GC/MS in Recent Years Has Defined the Normal and Clinically Disordered Steroidome: Will It Soon Be Surpassed by LC/Tandem MS in This Role?
Cedric Shackleton, Oscar J Pozo, Josep Marcos

J Endocr Soc· August 2018

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Attenuation of UVR-induced vitamin D synthesis in a mouse model deleted for keratinocyte lathosterol 5-desaturase.
Anastasia M Makarova, Saloni Pasta, Gordon Watson, Cedric Shackleton, Ervin H Epstein

J Steroid Biochem Mol Biol· July 2017

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Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients.
William J Griffiths, Jonas Abdel-Khalik, Peter J Crick, Michael Ogundare, Cedric H Shackleton

J Steroid Biochem Mol Biol· May 2017

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Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.
Wiebke Arlt, Katharina Lang, Alice J Sitch, Anna S Dietz, Yara Rhayem, Cedric Hl Shackleton

JCI Insight· April 2017

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Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty.
Jan Idkowiak, Angela E Taylor, Sandra Subtil, Donna M O'Neil, Raymon Vijzelaar, Cedric H L Shackleton

J Clin Endocrinol Metab· June 2016

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Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome.
Laura C Torchen, Jan Idkowiak, Naomi R Fogel, Donna M O'Neil, Cedric H L Shackleton

J Clin Endocrinol Metab· May 2016

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Delivery of the 7-dehydrocholesterol reductase gene to the central nervous system using adeno-associated virus vector in a mouse model of Smith-Lemli-Opitz Syndrome.
Saloni Pasta, Omoye Akhile, Dorothy Tabron, Flora Ting, Cedric Shackleton

Mol Genet Metab Rep· September 2015

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Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype.
Rachel K Crowley, Beverly Hughes, Joanna Gray, Theresa McCarthy, Susan Hughes, Cedric H L Shackleton

Eur J Endocrinol· October 2014

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Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.
Samantha L Rogers, Beverly A Hughes, Christopher A Jones, Lauren Freedman, Katherine Smart, Cedric H L Shackleton

J Clin Endocrinol Metab· May 2014

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Remission of hypertension and electrolyte abnormalities following renal transplantation in a patient with apparent mineralocorticoid excess well documented throughout childhood.
Ahmed M Khattab, Cedric H L Shackleton, Beverly A Hughes, Jayesh B Bodalia, Maria I New

J Pediatr Endocrinol Metab· January 2014

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Biochemical and Physiological Improvement in a Mouse Model of Smith-Lemli-Opitz Syndrome (SLOS) Following Gene Transfer with AAV Vectors.
Lee Ying, Xavier Matabosch, Montserrat Serra, Berna Watson, Cedric Shackleton

Mol Genet Metab Rep· January 2014

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Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2.
Silvia Parajes, Aliesha Griffin, Angela E Taylor, Ian T Rose, Irene Miguel-Escalada, Cedric Shackleton

Endocrinology· August 2013

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Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome.
Anna Meljon, Gordon L Watson, Yuqin Wang, Cedric H L Shackleton, William J Griffiths

Biochem Pharmacol· July 2013

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Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency.
Nicole Reisch, Jan Idkowiak, Beverly A Hughes, Hannah E Ivison, Omar A Abdul-Rahman, Cedric H L Shackleton

J Clin Endocrinol Metab· March 2013

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