Publications by authors named "Celine Valant"

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Structure-guided allosteric modulation of the delta opioid receptor.
Jesse I Mobbs, M Deborah Nguyen, Owindeep Deo, Damian Bartuzi, Hariprasad Venugopal, Celine Valant

bioRxiv· October 2025

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A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.
Owindeep Deo, Vi Pham, Sadia Alvi, Nicholas Barnes, Arisbel B Gondin, Celine Valant

ACS Chem Neurosci· August 2025

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Cryo-EM reveals an extrahelical allosteric binding site at the M mAChR.
Wessel A C Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Celine Valant

Nat Commun· July 2025

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The Prosperity and Adversity of M Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders.
Boqun Liu, Arthur Christopoulos, David M Thal, Ben Capuano, Celine Valant

J Med Chem· April 2025

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Cryo-EM reveals a new allosteric binding site at the M mAChR.
Wessel A C Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Celine Valant

bioRxiv· February 2025

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Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges.
Michaela G Kaoullas, David M Thal, Arthur Christopoulos, Celine Valant

Neuropharmacology· November 2024

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Ligand-directed biased agonism at human histamine H receptor isoforms across Gα- and β-arrestin2-mediated pathways.
Sabrina N Rahman, Faissal Imhaouran, Rob Leurs, Arthur Christopoulos, Céline Valant

Biochem Pharmacol· October 2024

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Positive allosteric modulation of a GPCR ternary complex.
Wessel A C Burger, Christopher J Draper-Joyce, Celine Valant, Arthur Christopoulos, David M Thal

Sci Adv· September 2024

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Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice.
Stella Liong, K H Christopher Choy, Simone N De Luca, Felicia Liong, Madison Coward-Smith, Celine Valant

Brain Behav Immun· August 2024

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Discovery of 2-Methyl-5-(1-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.
Boqun Liu, Geoff Thompson, Manuela Jörg, Nicholas Barnes, David M Thal, Celine Valant

J Med Chem· August 2024

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Opportunities and challenges for the development of M muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Huong T M Nguyen, Emma T van der Westhuizen, Christopher J Langmead, Andrew B Tobin, Patrick M Sexton, Celine Valant

Br J Pharmacol· July 2024

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Importance of receptor expression in the classification of novel ligands at the M muscarinic acetylcholine receptor.
Ye Jiang, Mahmuda Yeasmin, Arisbel B Gondin, Arthur Christopoulos, Celine Valant

Br J Pharmacol· July 2024

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Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Ayame Saito, Sadia Alvi, Celine Valant, Arthur Christopoulos, Simona E Carbone

Br J Pharmacol· July 2024

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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M mAChR.
Manuela Jörg, Emma T van der Westhuizen, Yao Lu, K H Christopher Choy, David M Shackleford, Celine Valant

Eur J Med Chem· October 2023

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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, Celine Valant

Br J Pharmacol· October 2023

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Role of Conserved Tyrosine Lid Residues in the Activation of the M Muscarinic Acetylcholine Receptor.
Vi Pham, Maria Clazina Cornelia Habben Jansen, Geoff Thompson, Laura H Heitman, Arthur Christopoulos, Celine Valant

Mol Pharmacol· September 2023

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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M mAChR.
Wessel A C Burger, Vi Pham, Ziva Vuckovic, Alexander S Powers, Jesse I Mobbs, Celine Valant

Nat Commun· September 2023

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Structural basis of efficacy-driven ligand selectivity at GPCRs.
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Celine Valant

Nat Chem Biol· July 2023

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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Celine Valant

Elife· May 2023

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Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Celine Valant

Nat Chem Biol· April 2023

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Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M.
Achi Haider, Xiaoyun Deng, Olivia Mastromihalis, Stefanie K Pfister, Troels E Jeppesen, Celine Valant

Acta Pharm Sin B· January 2023

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The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δOpioid Receptor.
Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M Thal, Celine Valant

J Med Chem· September 2022

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Biased Profile of Xanomeline at the Recombinant Human M Muscarinic Acetylcholine Receptor.
Jack K McDonald, Emma T van der Westhuizen, Vi Pham, Geoff Thompson, Christian C Felder, Celine Valant

ACS Chem Neurosci· April 2022

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Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.
Jesse J DiCello, Simona E Carbone, Ayame Saito, Vi Pham, Agata Szymaszkiewicz, Celine Valant

Am J Physiol Gastrointest Liver Physiol· January 2022

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Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy.
Matthew C L Wakeham, Briana J Davie, David K Chalmers, Arthur Christopoulos, Ben Capuano, Celine Valant

ACS Chem Neurosci· January 2022

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