Publications by authors named "Chander Digwal"

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Mapping Dysfunctional Protein-Protein Interactions in Disease.
Anna Rodina, Hediye Erdjument-Bromage, Mara Monetti, Zhuoning Li, Souparna Chakrabarty, Chander S Digwal

J Vis Exp· October 2025

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Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases.
Chiranjeevi Pasala, Chander S Digwal, Sahil Sharma, Shujuan Wang, Alessia Bubula

RSC Chem Biol· May 2025

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Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum.
Sadik Bay, Anna Rodina, Florence Haut, Tanaya Roychowdhury, Elentina K Argyrousi, Chander S Digwal

Res Sq· February 2025

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Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation.
Tanaya Roychowdhury, Seth W McNutt, Chiranjeevi Pasala, Hieu T Nguyen, Daniel T Thornton, Chander S Digwal

Nat Commun· October 2024

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N-Glycosylation-Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules.
Andrea Magni, Cristiano Sciva, Matteo Castelli, Chander S Digwal, Anna Rodina

Chemistry· September 2024

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Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders.
Sadik Bay, Chander S Digwal, Ananda M Rodilla Martín, Sahil Sharma, Aleksandra Stanisavljevic

Biomedicines· June 2024

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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation.
Seth W McNutt, Tanaya Roychowdhury, Chiranjeevi Pasala, Hieu T Nguyen, Daniel T Thornton, Chander S Digwal

Res Sq· April 2024

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Structural and functional complexity of HSP90 in cellular homeostasis and disease.
Gabriela Chiosis, Chander S Digwal, Jane B Trepel, Len Neckers

Nat Rev Mol Cell Biol· November 2023

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Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action.
Sahil Sharma, Suhasini Joshi, Teja Kalidindi, Chander S Digwal, Palak Panchal

Biomedicines· September 2023

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How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view.
Matteo Castelli, Pengrong Yan, Anna Rodina, Chander S Digwal, Palak Panchal

Structure· August 2023

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Synthesis, biological evaluation and mechanistic studies of 4-(1,3-thiazol-2-yl)morpholine-benzimidazole hybrids as a new structural class of antimicrobials.
Shams Aaghaz, Chander S Digwal, Naziya Neshat, Indresh K Maurya, Vinod Kumar

Bioorg Chem· July 2023

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Anna Rodina, Chao Xu, Chander S Digwal, Suhasini Joshi, Yogita Patel

Nat Commun· June 2023

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Editorial: Development of selective carbon-11 radioligands for target-based PET molecular imaging in oncology, cardiology and neurology.
Sridhar Goud Nerella, Manoj Kumar, Kiran Kumar Solingapuram Sai, Chander Singh Digwal

Front Med (Lausanne)· January 2023

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Synthesis of I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice.
Sahil Sharma, Teja Kalidindi, Suhasini Joshi, Chander S Digwal, Palak Panchal

STAR Protoc· June 2022

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Disease-specific interactome alterations via epichaperomics: the case for Alzheimer's disease.
Stephen D Ginsberg, Thomas A Neubert, Sahil Sharma, Chander S Digwal, Pengrong Yan

FEBS J· April 2022

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PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective.
Sridhar Goud Nerella, Priti Singh, Tulja Sanam, Chander Singh Digwal

Front Med (Lausanne)· February 2022

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Suhasini Joshi, Erica DaGama Gomes, Tai Wang, Adriana Corben, Tony Taldone, Chander S Digwal

Commun Biol· November 2021

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Alexander Bolaender, Danuta Zatorska, Huazhong He, Suhasini Joshi, Sahil Sharma, Chander S Digwal

Nat Commun· August 2021

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Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.
Swathi Merugu, Sahil Sharma, Justin Kaner, Chander Digwal, Mayumi Sugita

Methods Enzymol· June 2021

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A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.
Tony Taldone, Tai Wang, Anna Rodina, Naga Vara Kishore Pillarsetty, Chander S Digwal

Cold Spring Harb Perspect Biol· April 2020

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Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents.
P V Sri Ramya, Lalita Guntuku, Srinivas Angapelly, Shailaja Karri, Chander Singh Digwal

Bioorg Med Chem Lett· March 2018

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Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors.
P V Sri Ramya, Lalita Guntuku, Srinivas Angapelly, Chander Singh Digwal, Uppu Jaya Lakshmi

Eur J Med Chem· January 2018

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Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors.
P V Sri Ramya, Srinivas Angapelly, Andrea Angeli, Chander Singh Digwal, Mohammed Arifuddin

J Enzyme Inhib Med Chem· December 2017

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Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.
Kamala K Vasu, Chander Singh Digwal, Amit N Pandya, Dhaivat H Pandya, Jayesh A Sharma

Bioorg Med Chem Lett· December 2017

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Vanadium-Catalyzed Oxidative C(CO)-C(CO) Bond Cleavage for C-N Bond Formation: One-Pot Domino Transformation of 1,2-Diketones and Amidines into Imides and Amides.
Chander Singh Digwal, Upasana Yadav, P V Sri Ramya, Sravani Sana, Baijayantimala Swain

J Org Chem· July 2017

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