Publications by authors named "Changyang Zhou"

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Resolving the mRNA Encapsulation-Release Trade-off via Compensatory Forces in Engineered Ionizable Lipids.
Weixiang Gao, Kang An, Yishan Ma, Xiao Xu, Ziyue Wang, Changyang Zhou

Adv Mater· November 2025

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A Del(5-) mouse model of Williams syndrome shows coronary, aortic, and cerebral vascular abnormalities with behavioral deficits.
Laurens W J Bosman, Hamid El Azzouzi, Lieke Kros, Yanto Ridwan, Nicole van Vliet, Haibo Zhou, Changyang Zhou

PNAS Nexus· November 2025

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Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates.
Shaoshuai Mao, Wenbo Peng, Zhengyan Feng, Yang Chen, Jing Sun, Changyang Zhou

Nat Biotechnol· October 2025

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Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells.
Leilei Wu, Shutan Jiang, Meisong Shi, Tanglong Yuan, Yaqin Li, Changyang Zhou

Genome Biol· November 2024

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Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a.
Yajing Liu, Sensen Lou, Jinhui Li, Yuanhua Liu, Shisheng Huang, Changyang Zhou

Cell Discov· September 2024

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Incorporating Machine Learning Strategies to Smart Gloves Enabled by Dual-Network Hydrogels for Multitask Control and User Identification.
Jianwen Liu, Zhicheng Qiu, Hao Kan, Tao Guan, Changyang Zhou

ACS Sens· April 2024

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Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model.
Bi-Rong Cao, Yi-Ming Huang, Fu-Yun Tian, Jin-Hui Li, Chun-Long Xu, Chang-Yang Zhou

Acta Pharmacol Sin· November 2023

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A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice.
Jinhui Li, Zhixin Shen, Yajing Liu, Zixiang Yan, Yuanhua Liu, Changyang Zhou

Mol Ther· July 2023

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Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics.
Kailun Fang, Qidan Li, Yu Wei, Changyang Zhou, Wenhui Guo

Mol Cell Proteomics· March 2022

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Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos.
Yu Wei, Yingsi Zhou, Yajing Liu, Wenqin Ying, Ruiming Lv, Haibo Zhou, Changyang Zhou

Protein Cell· September 2021

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Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs.
Ni Gao, Jing Hu, Bingbing He, Zhengbang Ji, Xinde Hu, Yingsi Zhou, Changyang Zhou, Haibo Zhou

Nat Cell Biol· January 2021

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A Cas-embedding strategy for minimizing off-target effects of DNA base editors.
Yajing Liu, Changyang Zhou, Shisheng Huang, Lu Dang, Yu Wei, Yingsi Zhou

Nat Commun· November 2020

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A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.
Erwei Zuo, Yidi Sun, Tanglong Yuan, Bingbing He, Changyang Zhou

Nat Methods· June 2020

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CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration.
Changyang Zhou, Xinde Hu, Cheng Tang, Wenjia Liu, Shaoran Wang, Yingsi Zhou, Haibo Zhou

Natl Sci Rev· May 2020

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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Haibo Zhou, Jinlin Su, Xinde Hu, Changyang Zhou, He Li, Yingsi Zhou

Cell· April 2020

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Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice.
Jin-Jing Li, Xiang Lin, Cheng Tang, Ying-Qian Lu, Xinde Hu, Changyang Zhou

Natl Sci Rev· January 2020

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Allele-specific genome editing of imprinting genes by preferentially targeting non-methylated loci using Staphylococcus aureus Cas9 (SaCas9).
Yajing Liu, Jianan Li, Changyang Zhou, Bin Meng, Yu Wei

Sci Bull (Beijing)· November 2019

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Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis.
Changyang Zhou, Yidi Sun, Rui Yan, Yajing Liu, Erwei Zuo, Haibo Zhou

Nature· July 2019

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Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors.
Meiling Zhang, Changyang Zhou, Yu Wei, Chunlong Xu, Hong Pan

Genome Biol· May 2019

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Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.
Guang Yang, Changyang Zhou, Ran Wang, Shisheng Huang, Yu Wei

Cell Rep· January 2019

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Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.
He Zhang, Hong Pan, Changyang Zhou, Yu Wei, Wenqin Ying

Development· October 2018

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In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.
Haibo Zhou, Junlai Liu, Changyang Zhou, Ni Gao, Zhiping Rao

Nat Neurosci· March 2018

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Highly efficient base editing in human tripronuclear zygotes.
Changyang Zhou, Meiling Zhang, Yu Wei, Yidi Sun, Yun Sun

Protein Cell· October 2017

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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.
Erwei Zuo, Yi-Jun Cai, Kui Li, Yu Wei, Bang-An Wang, Changyang Zhou

Cell Res· July 2017

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Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL‑60 cells.
Ya-Jing Liu, Chang-Yang Zhou, Chun-Hong Qiu, Xiu-Min Lu, Yong-Tang Wang

Mol Med Rep· October 2013

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