Publications by authors named "Charles Harrington"

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Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease.
Lianne Robinson, Jack Bray, Valeria Melis, Charles R Harrington, Claude M Wischik

Behav Pharmacol· February 2026

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Systematic gait analysis in alpha-synuclein transgenic line 62 mice using the CatWalk.
Karima Schwab, Lianne Robinson, Jack Bray, Anne Anschuetz, Miguel Mondesir, Charles R Harrington

Behav Brain Res· January 2026

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Inhibiting Disulfide Bonding in Truncated Tau297-391 Results in Enhanced Self-Assembly of Tau into Seed-Competent Assemblies.
Sebastian S Oakley, Karen E Marshall, Georg Meisl, Alice Copsey, Mahmoud B Maina, Charles R Harrington

ACS Chem Neurosci· December 2025

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Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.
Mohammad Arastoo, Lewis K Penny, Richard Lofthouse, Aaron Hitchcock, Anna Moelders, Charles R Harrington

Sci Rep· November 2025

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A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine.
Youssra K Al-Hilaly, Janet E Rickard, Michael Simpson, John M D Storey, Charles R Harrington

J Mol Biol· September 2025

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Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer's disease: A meta-analysis 2015-2023.
Anne Anschuetz, Karima Schwab, Charles R Harrington, Claude M Wischik, Gernot Riedel

J Alzheimers Dis· September 2025

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Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain.
Renato X Santos, Sophie H Lee, Richard Lofthouse, Valeria Melis, Lianne Robinson, Charles R Harrington

FEBS J· May 2025

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Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia.
Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Charles R Harrington

Brain Res Bull· January 2025

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High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer's disease.
Mohammad Arastoo, Lewis K Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Charles R Harrington

Alzheimers Res Ther· October 2024

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Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine.
Anna L Cranston, Igor Kraev, Mike G Stewart, David Horsley, Renato X Santos, Charles R Harrington

Cell Signal· September 2024

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Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors.
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Charles R Harrington

Brain Res Bull· June 2024

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LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy.
Karima Schwab, Silke Frahm, Mandy Magbagbeolu, David Horsley, Elizabeth A Goatman, Charles R Harrington

Eur J Pharmacol· May 2024

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Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease.
Lewis K Penny, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R Harrington

Transl Neurodegener· May 2024

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Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington

Cells· April 2024

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Solubility of α-synuclein species in the L62 mouse model of synucleinopathy.
Karima Schwab, Mandy Magbagbeolu, Franz Theuring, Charles R Harrington, Claude M Wischik

Sci Rep· March 2024

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Assays for the Screening and Characterization of Tau Aggregation Inhibitors.
David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harrington

Methods Mol Biol· March 2024

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Apathy-like behaviour in tau mouse models of Alzheimer's disease and frontotemporal dementia.
Lianne Robinson, Eline Dreesen, Miguel Mondesir, Charles Harrington, Claude Wischik

Behav Brain Res· January 2024

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A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease.
Anne Anschuetz, Karima Schwab, Charles R Harrington, Claude M Wischik, Gernot Riedel

J Alzheimers Dis· January 2024

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Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants.
Mohammad Arastoo, Michael P Mazanetz, Sonya Miller, Helen Shiells, Claire Hull, Charles R Harrington

Int J Mol Sci· September 2023

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Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.
Constantin Kondak, Michael Leith, Thomas C Baddeley, Renato X Santos, Charles R Harrington

Int J Mol Sci· June 2023

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Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis.
Alex Zabala-Findlay, Lewis K Penny, Richard A Lofthouse, Andrew J Porter, Soumya Palliyil, Charles R Harrington

Cells· April 2023

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Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391).
Youssra K Al-Hilaly, Connor Hurt, Janet E Rickard, Charles R Harrington, John M D Storey

Front Neurosci· December 2022

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An Additive-Free Model for Tau Self-Assembly.
Youssra K Al-Hilaly, Karen E Marshall, Liisa Lutter, Luca Biasetti, Kurtis Mengham, Charles R Harrington

Methods Mol Biol· November 2022

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Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.
Mahmoud B Maina, Youssra K Al-Hilaly, Sebastian Oakley, Gunasekhar Burra, Tahmida Khanom, Charles R Harrington

J Mol Biol· October 2022

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Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Karima Schwab, Zoi Chasapopoulou, Silke Frahm, Mandy Magbagbeolu, Anna Cranston, Charles R Harrington

Cell Signal· September 2022

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