Publications by authors named "Charles Mosier"

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Dysregulation of huntingtin interacting protein networks in human juvenile Huntington's disease brain.
Sonia Podvin, Brin Rosenthal, Charles Mosier, Enlin Wei, Kathleen M Fisch

J Huntingtons Dis· November 2025

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Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer's Disease.
Vivian Hook, Sonia Podvin, Michael C Yoon, Von V Phan, Jazmin Florio, Charles Mosier

ACS Chem Biol· August 2025

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Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK.
Sonia Podvin, Jazmin Florio, Brian Spencer, Michael Mante, Estefani Guzman, Charles Mosier

ACS Chem Neurosci· April 2025

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Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems.
Sonia Podvin, Charles Mosier, William Poon, Enlin Wei, Leigh-Ana Rossitto

J Huntingtons Dis· December 2023

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Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin.
Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert

Extracell Vesicles Circ Nucl Acids· November 2023

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Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.
Michael C Yoon, Von Phan, Sonia Podvin, Charles Mosier, Anthony J O'Donoghue

Biochemistry· August 2023

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Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions.
Von V Phan, Charles Mosier, Michael C Yoon, Evgenia Glukhov, Conor R Caffrey

ACS Omega· July 2022

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Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases.
Michael C Yoon, Janneca Ames, Charles Mosier, Zhenze Jiang, Sonia Podvin

ACS Chem Neurosci· January 2022

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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.
Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Charles Mosier

ACS Chem Biol· September 2021

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Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier

ACS Omega· May 2021

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Vivian Hook, Michael Yoon, Charles Mosier, Gen Ito, Sonia Podvin

Biochim Biophys Acta Proteins Proteom· August 2020

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Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration.
Sonia Podvin, Holly T Reardon, Katrina Yin, Charles Mosier, Vivian Hook

J Neurol· March 2019

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Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles.
Christopher B Lietz, Thomas Toneff, Charles Mosier, Sonia Podvin, Anthony J O'Donoghue

J Am Soc Mass Spectrom· May 2018

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Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.
Holger Cynis, Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Michael Ziegler

Neurodegener Dis· May 2015

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Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.
Thomas Toneff, Lydiane Funkelstein, Charles Mosier, Armen Abagyan, Michael Ziegler

Peptides· August 2013

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Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.
Lydiane Funkelstein, W Douglas Lu, Britta Koch, Charles Mosier, Thomas Toneff

J Biol Chem· May 2012

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Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.
Jill L Wegrzyn, Steven J Bark, Lydiane Funkelstein, Charles Mosier, Angel Yap

J Proteome Res· October 2010

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Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin.
Vivian Hook, Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Shin-Rong Hwang

Endocrine· June 2009

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Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression.
Lydiane Funkelstein, Thomas Toneff, Charles Mosier, Shin-Rong Hwang, Felix Beuschlein

J Biol Chem· December 2008

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Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
Shin-Rong Hwang, Christina Garza, Charles Mosier, Thomas Toneff, Eric Wunderlich

J Biol Chem· March 2007

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