Publications by authors named "Cheng-Tai Lu"

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Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
Hsin-Huei Chang, Lung-Chun Lee, Tsu Hsu, Yi-Hui Peng, Chih-Hsiang Huang, Cheng-Tai Lu

J Med Chem· December 2024

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Dynamic Tracking and Real-Time Fall Detection Based on Intelligent Image Analysis with Convolutional Neural Network.
Ching-Bang Yao, Cheng-Tai Lu

Sensors (Basel)· November 2024

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Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
Lung-Chun Lee, Yi-Hui Peng, Hsin-Huei Chang, Tsu Hsu, Cheng-Tai Lu

J Med Chem· August 2021

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Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease.
Zheng-Sheng Lai, Teng-Kuang Yeh, Yu-Chi Chou, Tsu Hsu, Cheng-Tai Lu

Eur J Med Chem· January 2021

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Cheng-Tai Lu, Chen-Lung Huang

J Med Chem· December 2019

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Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.
Tsung-Sheng Wu, Wen-Hsing Lin, Hui-Jen Tsai, Ching-Cheng Hsueh, Tsu Hsu, Cheng-Tai Lu, Lung-Chun Lee

J Med Chem· April 2019

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Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).
Chih-Hsiang Tu, Wen-Hsing Lin, Yi-Hui Peng, Tsu Hsu, Jian-Sung Wu, Cheng-Tai Lu

J Med Chem· April 2016

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Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.
Chiung-Tong Chen, John T-A Hsu, Wen-Hsing Lin, Cheng-Tai Lu, Shih-Chieh Yen, Chen-Lung Huang

Eur J Med Chem· July 2015

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Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.
Hui-Yi Shiao, Mohane Selvaraj Coumar, Chun-Wei Chang, Yi-Yu Ke, Ya-Hui Chi, Cheng-Tai Lu

J Med Chem· July 2013

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Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Wen-Hsing Lin, John T-A Hsu, Shu-Yi Hsieh, Chiung-Tong Chen, Jen-Shin Song, Cheng-Tai Lu

Bioorg Med Chem· June 2013

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3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
John T-A Hsu, Teng-Kuang Yeh, Shih-Chieh Yen, Chiung-Tong Chen, Shu-Yi Hsieh, Cheng-Tai Lu

Bioorg Med Chem Lett· July 2012

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Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Wen-Hsing Lin, Shu-Yi Hsieh, Shih-Chieh Yen, Chiung-Tong Chen, Teng-Kuang Yeh, Cheng-Tai Lu

Bioorg Med Chem· July 2011

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Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.
Ting-Yueh Tsai, Tsu Hsu, Chiung-Tong Chen, Jai-Hong Cheng, Teng-Kuang Yeh, Chen-Lung Huang, Cheng-Tai Lu

Bioorg Med Chem· March 2009

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