Publications by authors named "Ching-Cheng Hsueh"

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Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix.
Yi-Hui Peng, Mu-Chun Li, Wan-Ching Yen, Teng-Kuang Yeh, Ching-Cheng Hsueh

J Med Chem· June 2025

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Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
Hsin-Huei Chang, Lung-Chun Lee, Tsu Hsu, Yi-Hui Peng, Chih-Hsiang Huang, Ching-Cheng Hsueh

J Med Chem· December 2024

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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Teng-Kuang Yeh, Jen-Shin Song, Po-Wei Chang, Jin-Chen Yu, Chia-Hwa Chang, Ching-Cheng Hsueh

Eur J Med Chem· February 2022

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Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
Lung-Chun Lee, Yi-Hui Peng, Hsin-Huei Chang, Tsu Hsu, Cheng-Tai Lu, Ching-Cheng Hsueh

J Med Chem· August 2021

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Correction to Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Ching-Cheng Hsueh

J Med Chem· July 2020

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Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Ching-Cheng Hsueh

J Med Chem· February 2020

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Ching-Cheng Hsueh

J Med Chem· December 2019

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Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.
Tsung-Sheng Wu, Wen-Hsing Lin, Hui-Jen Tsai, Ching-Cheng Hsueh, Tsu Hsu

J Med Chem· April 2019

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Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Yi-Hui Peng, Shau-Hua Ueng, Chen-Tso Tseng, Ming-Shiu Hung, Jen-Shin Song, Ching-Cheng Hsueh

J Med Chem· January 2016

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Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, Ching-Cheng Hsueh

Proc Natl Acad Sci U S A· May 2013

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