Publications by authors named "Chengyong Wu"

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Structure-guided design of potent tetrazolo[1,5-a]pyrimidine-based tubulin inhibitors with in vivo antitumor activity.
Yaolin Guo, Quanwei Yu, Cuiyu Guo, Chengyong Wu, Lun Tan

Eur J Med Chem· January 2026

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A Dichloropropionamide-Substituted Diaminopyrimidine EGFR-TKI Overcomes Osimertinib Resistance in NSCLC via Dual Anchoring at Ser797 and Met793.
Yuying Wang, Quanwei Yu, Xiongqi Yang, Lingling Ma, Ridong Huang, Zhenru Wu, Chengyong Wu

J Med Chem· December 2025

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Discovery of Novel 4,5-Dihydropyrrolo[3,4-]pyrazol-6()-one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity.
Quanwei Yu, Yujie Liu, Zhijia Wang, Chengyong Wu, Ruofei Zhang

J Med Chem· October 2025

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Hydrophobic interaction-driven binding of ensifentrine stabilizes PDE3A: insights from X-ray crystallography and molecular dynamics.
Shuangshuang Li, Quanwei Yu, Liyun Bi, Yuxi Wang, Chengyong Wu

Phys Chem Chem Phys· October 2025

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IL-17A as a Key Mediator of Pulmonary-Intestinal Immune Interactions in a Mouse Model of Asthma and Colitis.
Chengyong Wu, Xuxu Hu, Zhongyuan Mo, Yan Meng, Yingying Du

J Inflamm Res· June 2025

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Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies.
Dan Zhang, Jifa Zhang, Chengyong Wu, Yao Xiao, Liwei Ji

ACS Cent Sci· May 2025

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Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site.
Qinhuai Lai, Zhijia Wang, Chengyong Wu, Ruofei Zhang, Leyan Li

Eur J Med Chem· February 2025

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Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway.
Kexin Wang, Lin Wang, Chengyong Wu, Hongxiang Chen, Donghui Cai

J Biochem Mol Toxicol· February 2025

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A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy.
Huan Xiao, Aoxue Wang, Wen Shuai, Yuping Qian, Chengyong Wu

Signal Transduct Target Ther· February 2025

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The relationship between long non-coding gene polymorphisms and cervical cancer.
Lili Han, Jing Liu, Mireayi Shataer, Chengyong Wu, Mayinuer Niyazi

Cancer Biol Ther· December 2024

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Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma.
Chenglong Xu, Chengyong Wu, Ling Li, Huiting Zhao, Jin Liu

Eur J Med Chem· November 2024

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Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Chengyong Wu, Lele Zhang, Zhilan Zhou, Lun Tan, Zhijia Wang

Eur J Med Chem· October 2024

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Emerging trends in small molecule inhibitors targeting aldosterone synthase: A new paradigm in cardiovascular disease treatment.
Cuiyu Guo, Guangbing Zhang, Chengyong Wu, Yi Lei, Yuxi Wang

Eur J Med Chem· August 2024

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Target proteins-regulated DNA nanomachine-electroactive substance complexes enable separation-free electrochemical detection of clinical exosome.
Xianghu Zeng, Chengyong Wu, Ying Xiong, Zixuan Zhan, Congcong Shen

Biosens Bioelectron· July 2024

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Steric Hindrance-Mediated Enzymatic Reaction Enable Homogeneous Dual Fluorescence Indicators Aptasensing of Hepatocellular Carcinoma CTCs.
Pengjun Jiang, Zixuan Zhan, Yufu Peng, Chengyong Wu, Yue Wang, Longfei Wu, Binwu Ying

Anal Chem· July 2024

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Development and therapeutic implications of small molecular inhibitors that target calcium-related channels in tumor treatment.
Linxi Zhang, Changyu Ren, Jiao Liu, Shuai Huang, Chengyong Wu

Drug Discov Today· June 2024

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Biomolecules-mediated electrochemical signals of Cu: Y-DNA nanomachines enable homogeneous rapid one-step assay of lung cancer circulating tumor cells.
Chengyong Wu, Li Yan, Zixuan Zhan, Runlian Qu, Yue Wang

Biosens Bioelectron· April 2024

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Self-Assembled DNA Machine and Selective Complexation Recognition Enable Rapid Homogeneous Portable Quantification of Lung Cancer CTCs.
Yue Wang, Congcong Shen, Chengyong Wu, Zixuan Zhan, Runlian Qu

Research (Wash D C)· April 2024

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Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery.
Jialin Wu, Xiaoxue Li, Chengyong Wu, Yuxi Wang, Jifa Zhang

Eur J Med Chem· March 2024

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Single-Cell Liquid Biopsy of Lung Cancer: Ultra-Simplified Efficient Enrichment of Circulating Tumor Cells and Hand-Held Fluorometer Portable Testing.
Yaqin He, Zixuan Zhan, Li Yan, Chengyong Wu, Yue Wang, Binwu Ying

ACS Nano· February 2024

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Design, Synthesis, and Biological Evaluation of Dual Inhibitors of EGFR/ACK1 to Overcome Osimertinib Resistance in Nonsmall Cell Lung Cancers.
Aoxue Wang, Wen Shuai, Chengyong Wu, Junping Pei, Panpan Yang

J Med Chem· February 2024

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Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials.
Jiani Yuan, Jiaxing Wang, Xiaoxue Li, Ya Zhang, Jinghong Xian, Chengyong Wu

Eur J Med Chem· October 2023

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Inhibition of γ-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation.
Cancan Zhang, Huisha Xu, Keilah G Netto, Leon A Sokulsky, Yiyan Miao, Chengyong Wu

Front Immunol· June 2023

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X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Yichang Ren, Yuxi Wang, Jin Liu, Ting Liu, Lin Yuan, Chengyong Wu

J Med Chem· May 2023

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Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer.
Junping Pei, Guan Wang, Aoxue Wang, Chengyong Wu, Xiaoli Pan

J Med Chem· April 2023

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