Publications by authors named "Quanwei Yu"

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Structure-guided design of potent tetrazolo[1,5-a]pyrimidine-based tubulin inhibitors with in vivo antitumor activity.
Yaolin Guo, Quanwei Yu, Cuiyu Guo, Chengyong Wu, Lun Tan, Yuxi Wang

Eur J Med Chem· January 2026

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A Dichloropropionamide-Substituted Diaminopyrimidine EGFR-TKI Overcomes Osimertinib Resistance in NSCLC via Dual Anchoring at Ser797 and Met793.
Yuying Wang, Quanwei Yu, Xiongqi Yang, Lingling Ma, Ridong Huang

J Med Chem· December 2025

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Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase IIα inhibitors for the therapy of small cell lung cancer.
Xuemei Deng, Xiongqi Yang, Quanwei Yu, Zhenqiang Xia, Yuying Wang

Bioorg Med Chem· November 2025

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In-Field Molecular Diagnostics of Plant Pathogens Using Bioluminescent CRISPR-Guided Caspase Assay.
Yipin Hu, Haohao Yan, Yong Zhang, Quanwei Yu, Ting Xue, Yuanhong Xu

Angew Chem Int Ed Engl· October 2025

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Discovery of Novel 4,5-Dihydropyrrolo[3,4-]pyrazol-6()-one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity.
Quanwei Yu, Yujie Liu, Zhijia Wang, Chengyong Wu, Ruofei Zhang, Cuiyu Guo, Yuxi Wang

J Med Chem· October 2025

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Hydrophobic interaction-driven binding of ensifentrine stabilizes PDE3A: insights from X-ray crystallography and molecular dynamics.
Shuangshuang Li, Quanwei Yu, Liyun Bi, Yuxi Wang, Chengyong Wu

Phys Chem Chem Phys· October 2025

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Discovery of a novel Thiazole amide inhibitor of Inflammasome and Pyroptosis pathways.
Zhen Dai, Ke Wang, Chenli Bai, Yong Li, Quanwei Yu, Yuxi Wang

Bioorg Chem· June 2025

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Image-Based Phenotypic Profiling Enables Rapid and Accurate Assessment of EGFR-Activating Mutations in Tissues from Lung Cancer Patients.
Qian Lei, Xinglong Zhou, Ying Li, Shuang Zhao, Na Yang, Quanwei Yu

J Am Chem Soc· February 2025

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Correction for Li et al., "SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII".
Ying Li, Quanwei Yu, Ridong Huang, Hai Chen, Hequan Ren

mBio· February 2025

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Synthesis, Structural Modification, and Antismall Cell Lung Cancer Activity of 3-Arylisoquinolines with Dual Inhibitory Activity on Topoisomerase I and II.
Xuemei Deng, Yuying Wang, Xiongqi Yang, Quanwei Yu, Ridong Huang

J Med Chem· February 2025

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Dynamic, Single-cell Monitoring of RNA Modifications Response to Viral Infection Using a Genetically Encoded Live-cell RNA Methylation Sensor.
Ting Zhang, Hao Yang, Quanwei Yu, Yong Zhang, Yue Zhang

Angew Chem Int Ed Engl· February 2025

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Design, synthesis and biological evaluation of naphthyl amide derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Quanwei Yu, Chao Song, Liyun Bi, Shuang Zhao, Qian Lei, Yuxi Wang

Bioorg Med Chem· September 2024

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Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase.
Yangyang Chen, Yang Li, Jing Gao, Quanwei Yu, Yiwen Zhang

Eur J Med Chem· May 2024

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Therapeutic potential of targeting polo-like kinase 4.
Qian Lei, Quanwei Yu, Na Yang, Zhaolin Xiao, Chao Song

Eur J Med Chem· February 2024

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RIPK2 inhibitors for disease therapy: Current status and perspectives.
Erkang Tian, Changhan Zhou, Shuqi Quan, Chongying Su, Guanning Zhang, Quanwei Yu

Eur J Med Chem· November 2023

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Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery.
Wentao Tang, Congcong Lin, Quanwei Yu, Dan Zhang, Yun Liu

J Med Chem· June 2023

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SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII.
Ying Li, Quanwei Yu, Ridong Huang, Hai Chen, Hequan Ren

mBio· April 2023

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Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site.
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Yuxi Wang

J Med Chem· March 2023

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Novel thermo and ion-responsive copolymers based on metallo-base pair directed host-guest complexation for highly selective recognition of Hg in aqueous solution.
Xing-Long Zhou, Chang-Hai Zhou, Jue-Ying Gong, Quan-Wei Yu, Yang He

J Hazard Mater· March 2023

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A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations.
Hui Deng, Qian Lei, Chengdi Wang, Zhoufeng Wang, Hai Chen, Quanwei Yu

Nat Commun· November 2022

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Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.
Xiaoling Hu, Junfang Li, Honghua Zhang, Quanwei Yu, Yuying Wang

Eur J Med Chem· October 2022

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Simultaneous Monitoring of HOCl and Viscosity with Drug-Induced Pyroptosis in Live Cells and Acute Lung Injury.
Zixuan Zhan, Qian Lei, Yongcheng Dai, Denian Wang, Quanwei Yu

Anal Chem· September 2022

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Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia.
Yancheng Yu, Fulai Yang, Quanwei Yu, Simeng Liu, Chenyang Wu

J Med Chem· December 2021

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The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Zhenqiang Xia, Ridong Huang, Xinglong Zhou, Yingying Chai, Hai Chen, Quanwei Yu

Eur J Med Chem· November 2021

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Application of cation-π interactions in enzyme-substrate binding: Design, synthesis, biological evaluation, and molecular dynamics insights of novel hydrophilic substrates for NQO1.
Qijie Gong, Quanwei Yu, Nan Wang, Jiabao Hu, Pengfei Wang

Eur J Med Chem· October 2021

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