Publications by authors named "Chengzao Sun"

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Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling.
Beverly Knight, Brinda Tammara, Nishit B Modi, Shannon Dallas, Saro Mardirosian, Chengzao Sun

Dermatol Ther (Heidelb)· September 2025

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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Anne M Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Chengzao Sun

Sci Rep· July 2024

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Cyclic Peptide Linker Design and Optimization by Molecular Dynamics Simulations.
Lei Yu, Stephanie A Barros, Chengzao Sun, Sandeep Somani

J Chem Inf Model· November 2023

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Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor.
Pierre Morissette, Nianyu Li, Jeanine E Ballard, Marissa Vavrek, Gregory L Adams, Chengzao Sun

Toxicol Sci· January 2022

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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na1.7 for the Treatment of Pain.
Gregory L Adams, Parul S Pall, Steven M Grauer, Xiaoping Zhou, Jeanine E Ballard, Chengzao Sun

J Med Chem· January 2022

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Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids.
James L Trevaskis, Christine M Mack, Chengzao Sun, Christopher J Soares, Lawrence J D'Souza

PLoS One· May 2014

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Bifunctional PEGylated exenatide-amylinomimetic hybrids to treat metabolic disorders: an example of long-acting dual hormonal therapeutics.
Chengzao Sun, James L Trevaskis, Carolyn M Jodka, Swetha Neravetla, Pete Griffin

J Med Chem· November 2013

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Native chemical ligation derived method for recombinant peptide/protein C-terminal amidation.
Chengzao Sun, Gary Luo, Swetha Neravetla, Soumitra S Ghosh, Bruce Forood

Bioorg Med Chem Lett· September 2013

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Synthesis, characterization, and reaction of a ketone-derived 1,4-dienolate compound.
Gerald Kagan, Weibin Li, Chengzao Sun, Russell Hopson, Paul G Williard

J Org Chem· January 2011

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Prevention of drug-induced memory impairment by immunopharmacotherapy.
Jennifer B Treweek, Chengzao Sun, Alexander V Mayorov, Longwu Qi, Coree L Levy

J Med Chem· November 2008

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Characterization of a chiral enolate aggregate and observation of 6Li-1H scalar coupling.
Deyu Li, Chengzao Sun, Paul G Williard

J Am Chem Soc· September 2008

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Analysis of an asymmetric addition with a 2:1 mixed lithium amide/n-butyllithium aggregate.
Jia Liu, Deyu Li, Chengzao Sun, Paul G Williard

J Org Chem· June 2008

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Aggregation studies of complexes containing a chiral lithium amide and n-Butyllithium.
Deyu Li, Chengzao Sun, Jia Liu, Russell Hopson, Weibin Li

J Org Chem· March 2008

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A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture media.
Steven W Taylor, Chengzao Sun, Amy Hsieh, Nancy L Andon, Soumitra S Ghosh

J Proteome Res· February 2008

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Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells.
Simon E Aspland, Carlo Ballatore, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun

Bioorg Med Chem Lett· October 2006

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The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity.
Chengzao Sun, Simon E Aspland, Carlo Ballatore, Rosario Castillo, Amos B Smith

Bioorg Med Chem Lett· January 2006

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Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
Wenyuan Wu, Yunping Luo, Chengzao Sun, Yuan Liu, Paul Kuo

Cancer Res· January 2006

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A facile route to paclitaxel C-10 carbamates.
Carlo Ballatore, Simon E Aspland, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun

Bioorg Med Chem Lett· May 2005

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Enzymatic incorporation of an antibody-activated blue fluorophore into DNA.
Gunnar F Kaufmann, Michael M Meijler, Chengzao Sun, Da-Wei Chen, David P Kujawa

Angew Chem Int Ed Engl· March 2005

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A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents.
Antonietta M Lillo, Chengzao Sun, Changshou Gao, Henrik Ditzel, Jay Parrish

Chem Biol· July 2004

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Solid-phase synthesis of anandamide analogues.
Longwu Qi, Michael M Meijler, Sang-Hyeup Lee, Chengzao Sun, Kim D Janda

Org Lett· May 2004

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Synthesis and biological validation of a ubiquitous quorum-sensing molecule.
Michael M Meijler, Louis G Hom, Gunnar F Kaufmann, Kathleen M McKenzie, Chengzao Sun

Angew Chem Int Ed Engl· April 2004

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Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Cheng Liu, Chengzao Sun, Haining Huang, Kim Janda, Thomas Edgington

Cancer Res· June 2003

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Enabling ScFvs as multi-drug carriers: a dendritic approach.
Chengzao Sun, Peter Wirsching, Kim D Janda

Bioorg Med Chem· April 2003

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Phage-display selection of a human single-chain fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized G(M3)-carbohydrate antigen.
Kyung Joo Lee, Shenlan Mao, Chengzao Sun, Changshou Gao, Ola Blixt

J Am Chem Soc· October 2002

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