Publications by authors named "Chi Shing Sum"

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Fine-tuning affinity and spacer design enhances T cell potency in DLL3 and BCMA CAR T cells.
Nicholas Mazzanti, Ninkka Tamot, Andrea Francese, Jinquan Luo, M Jack Borrok, Chi Shing Sum

MAbs· December 2026

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An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Jing Yang, Claudio Mapelli, Zhaoqing Wang, Chi Shing Sum, Ji Hua

Platelets· October 2022

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Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
E Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Chi Shing Sum

J Med Chem· July 2022

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Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
Peter T W Cheng, Robert F Kaltenbach, Hao Zhang, Jun Shi, Shiwei Tao, Chi Shing Sum

J Med Chem· November 2021

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Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.
Robert J Wilson, Edgars Jecs, Eric J Miller, Huy H Nguyen, Yesim A Tahirovic, Chi Shing Sum

ACS Med Chem Lett· January 2018

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Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
Andrew Alt, Annapurna Pendri, Robert L Bertekap, Guo Li, Yulia Benitex, Chi Shing Sum

J Pharmacol Exp Ther· February 2016

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GPCR profiling: from hits to leads and from genotype to phenotype.
Mary Ellen Cvijic, Chi Shing Sum, Andrew Alt, Litao Zhang

Drug Discov Today Technol· November 2015

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Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds.
Chi Shing Sum, Debra Nickischer, Ming Lei, Andrea Weston, Litao Zhang

Curr Chem Genom Transl Med· March 2014

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Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.
Chi Shing Sum, Irina G Tikhonova, Stefano Costanzi, Marvin C Gershengorn

J Biol Chem· February 2009

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Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.
Irina G Tikhonova, Chi Shing Sum, Susanne Neumann, Stanislav Engel, Bruce M Raaka

J Med Chem· February 2008

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Identification of residues important for agonist recognition and activation in GPR40.
Chi Shing Sum, Irina G Tikhonova, Susanne Neumann, Stanislav Engel, Bruce M Raaka

J Biol Chem· October 2007

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Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor.
Alejandro T Colozo, Paul S-H Park, Chi Shing Sum, Luca F Pisterzi, James W Wells

Biochem Pharmacol· July 2007

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Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.
Irina G Tikhonova, Chi Shing Sum, Susanne Neumann, Craig J Thomas, Bruce M Raaka

J Med Chem· June 2007

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Effects of N-ethylmaleimide on conformational equilibria in purified cardiac muscarinic receptors.
Chi Shing Sum, Paul S-H Park, James W Wells

J Biol Chem· September 2002

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Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors.
Paul S-H Park, Chi Shing Sum, Asha B Pawagi, James W Wells

Biochemistry· April 2002

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