Publications by authors named "Chirag Krishna"

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HIGHER HLA-DRB1 EVOLUTIONARY DIVERGENCE (HED) IS ASSOCIATED WITH REDUCED RELAPSE AND IMPROVED SURVIVAL AFTER MATCHED UNRELATED HEMATOPOIETIC CELL TRANSPLANTATION.
Jennifer N Saultz, Yung-Tsi Bolon, Tao Wang, Steve Spellman, Stephanie Lee, Chirag Krishna

Transplant Cell Ther· December 2025

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Innate immune cell subsets are enriched in synovial fluid of ACPA-negative rheumatoid arthritis and characterized by distinct type I IFN gene signatures.
Alexandra Argyriou, Marc H Wadsworth, Joshua Fienman, Ana Cristina Gonzalez-Sanchez, Salim Ghannoum, Chirag Krishna

Ann Rheum Dis· October 2025

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Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation.
Stanislav Dikiy, Aazam P Ghelani, Andrew G Levine, Stephen Martis, Paolo Giovanelli, Chirag Krishna

Nat Immunol· March 2025

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Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab.
Tyler J Alban, Nadeem Riaz, Prerana Parthasarathy, Vladimir Makarov, Sviatoslav Kendall, Chirag Krishna

Nat Med· November 2024

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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.
Tihana Trsan, Vincent Peng, Chirag Krishna, Takahiro E Ohara, Wandy L Beatty, Praveen Krishnamoorthy

Dev Cell· September 2024

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The influence of HLA genetic variation on plasma protein expression.
Chirag Krishna, Joshua Chiou, Saori Sakaue, Joyce B Kang, Stephen M Christensen

Nat Commun· July 2024

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Efficient and accurate mixed model association tool for single-cell eQTL analysis.
Wei Zhou, Anna S E Cuomo, Angli Xue, Masahiro Kanai, Grant Chau, Chirag Krishna

medRxiv· May 2024

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Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses.
Marta Brandt, Zhifang Cao, Chirag Krishna, Jennifer L Reedy, Xiebin Gu

Cell Rep· March 2024

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An immunogenetic basis for lung cancer risk.
Chirag Krishna, Anniina Tervi, Miriam Saffern, Eric A Wilson, Seong-Keun Yoo

Science· February 2024

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The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T Carter, Elizabeth A Creasey, Chirag Krishna, Ashwin N Ananthakrishnan

Immunity· December 2023

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Unsupervised and supervised AI on molecular dynamics simulations reveals complex characteristics of HLA-A2-peptide immunogenicity.
Jeffrey K Weber, Joseph A Morrone, Seung-Gu Kang, Leili Zhang, Lijun Lang, Chirag Krishna

Brief Bioinform· November 2023

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The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Lingjia Kong, Vladislav Pokatayev, Ariel Lefkovith, Grace T Carter, Elizabeth A Creasey, Chirag Krishna, Ashwin N Ananthakrishnan

Immunity· February 2023

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Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Briana G Nixon, Fengshen Kuo, LiangLiang Ji, Ming Liu, Kristelle Capistrano, Chirag Krishna

Immunity· November 2022

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Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.
Emily R Kansler, Saïda Dadi, Chirag Krishna, Briana G Nixon, Efstathios G Stamatiades

Nat Immunol· August 2022

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Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.
Emily R Kansler, Saïda Dadi, Chirag Krishna, Briana G Nixon, Efstathios G Stamatiades

Nat Immunol· June 2022

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Programme of self-reactive innate-like T cell-mediated cancer immunity.
Chun Chou, Xian Zhang, Chirag Krishna, Briana G Nixon, Saida Dadi

Nature· May 2022

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Improved prediction of immune checkpoint blockade efficacy across multiple cancer types.
Diego Chowell, Seong-Keun Yoo, Cristina Valero, Alessandro Pastore, Chirag Krishna

Nat Biotechnol· April 2022

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Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity.
Briana G Nixon, Chun Chou, Chirag Krishna, Saïda Dadi, Adam O Michel

Sci Immunol· April 2022

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Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation.
Charles Kyriakos Vorkas, Chirag Krishna, Kelin Li, Jeffrey Aubé, Daniel W Fitzgerald

J Immunol· March 2022

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Rules of Engagement: The Lymphocyte Receptor Ecosystem in Renal Cell Carcinoma.
Chirag Krishna, A Ari Hakimi

Cancer Res· March 2022

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Mutations in and differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.
Robert M Samstein, Chirag Krishna, Xiaoxiao Ma, Xin Pei, Ken-Wing Lee

Nat Cancer· December 2021

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High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab.
Chung-Han Lee, Renzo G DiNatale, Diego Chowell, Chirag Krishna, Vladimir Makarov

Mol Cancer Res· September 2021

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Qa-1 Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing.
Xiao Zhang, Erich Sabio, Chirag Krishna, Xiaoxiao Ma, Jingming Wang

Mol Cancer Res· June 2021

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Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
Chirag Krishna, Renzo G DiNatale, Fengshen Kuo, Raghvendra M Srivastava, Lynda Vuong

Cancer Cell· May 2021

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Genetic and environmental determinants of human TCR repertoire diversity.
Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati, Timothy A Chan

Immun Ageing· September 2020

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