Publications by authors named "Christian B Lessard"

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Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity.
Christian B Lessard, Diego Rubio-Rubio, Samantha Tolton, Marangelie Criado-Marrero, Sakthivel Ravi

bioRxiv· July 2025

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Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
Kristen R Ibanez, Karen N McFarland, Jennifer Phillips, Mariet Allen, Christian B Lessard

Alzheimers Res Ther· July 2022

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Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda

Acta Neuropathol· March 2021

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γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne

Alzheimers Res Ther· May 2020

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Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne

J Biol Chem· July 2019

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Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Lorenza Magno, Christian B Lessard, Marta Martins, Verena Lang, Pedro Cruz

Alzheimers Res Ther· February 2019

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High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz

EMBO Mol Med· November 2018

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γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd

EMBO Mol Med· July 2017

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γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde

PLoS One· June 2016

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A nuclear function for the presenilin 1 neuronal partner NPRAP/δ-catenin.
Carolina Koutras, Christian B Lessard, Georges Lévesque

J Alzheimers Dis· August 2012

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Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
Sarah A Sagi, Christian B Lessard, Kellen D Winden, Hiroko Maruyama, Jeremy C Koo

J Biol Chem· November 2011

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And four equals one: presenilin takes the gamma-secretase role by itself.
Christian B Lessard, Steven L Wagner, Edward H Koo

Proc Natl Acad Sci U S A· December 2010

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The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
Christian B Lessard, Marc P Lussier, Sylvie Cayouette, Geneviève Bourque, Guylain Boulay

Cell Signal· April 2005

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