Publications by authors named "Kellen D Winden"

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Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models.
Wardiya Afshar-Saber, Juan F Ruiz, Isabel Gisser, Ziqin Yang, Leena Mehendale, Kellen D Winden

Cell Rep· December 2025

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Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes.
Angelica D'Amore, Maria Sundberg, Rui Lin, Ella T Lubbers, Kellen D Winden

Mol Psychiatry· July 2025

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An open-source pipeline for calcium imaging and all-optical physiology in human stem cell-derived neurons.
Wardiya Afshar-Saber, Federico M Gasparoli, Ziqin Yang, Nicole A Teaney, Lahin Lalani, Kellen D Winden

bioRxiv· July 2025

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Construction destruction: Contribution of dyregulated proteostasis to neurodevelopmental disorders.
Kellen D Winden, Juan F Ruiz, Mustafa Sahin

Curr Opin Neurobiol· February 2025

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Using cortical organoids to understand the pathogenesis of malformations of cortical development.
Kellen D Winden, Isabel Gisser, Mustafa Sahin

Front Neurosci· January 2025

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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations.
Wardiya Afshar-Saber, Nicole A Teaney, Kellen D Winden, Hellen Jumo, Xutong Shi

Neurobiol Dis· January 2024

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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.
Kellen D Winden, Truc T Pham, Nicole A Teaney, Juan Ruiz, Ryan Chen

Cell Rep· August 2023

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16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons.
Elizabeth D Buttermore, Nickesha C Anderson, Pin-Fang Chen, Nina R Makhortova, Kristina H Kim, Kellen D Winden

Front Psychiatry· November 2022

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Translating Ribosome Affinity Purification (TRAP) of Cell Type-specific mRNA from Mouse Brain Lysates.
Catherine L Salussolia, Kellen D Winden, Mustafa Sahin

Bio Protoc· May 2022

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Arthritis flares mediated by tissue-resident memory T cells in the joint.
Margaret H Chang, Anaïs Levescot, Nathan Nelson-Maney, Rachel B Blaustein, Kellen D Winden

Cell Rep· October 2021

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Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.
Jasbir Singh Dalal, Kellen Diamond Winden, Catherine Lourdes Salussolia, Maria Sundberg, Achint Singh

Elife· July 2021

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16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Maria Sundberg, Hannah Pinson, Richard S Smith, Kellen D Winden, Pooja Venugopal

Nat Commun· May 2021

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Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile.
Krinio Giannikou, Zachary Zhu, Jaegil Kim, Kellen D Winden, Magdalena E Tyburczy

Mod Pathol· February 2021

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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Alessia Di Nardo, Isadora Lenoël, Kellen D Winden, Alina Rühmkorf, Meera E Modi

Cell Rep· June 2020

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Biallelic Mutations in Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons.
Kellen D Winden, Maria Sundberg, Cindy Yang, Syed M A Wafa, Sean Dwyer

J Neurosci· November 2019

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Abnormal mTOR Activation in Autism.
Kellen D Winden, Darius Ebrahimi-Fakhari, Mustafa Sahin

Annu Rev Neurosci· July 2018

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Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy.
Kellen D Winden, Anatol Bragin, Jerome Engel, Dan H Geschwind

Neurobiol Dis· June 2015

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Megalencephaly and Macrocephaly.
Kellen D Winden, Christopher J Yuskaitis, Annapurna Poduri

Semin Neurol· June 2015

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Stroke in primary hyperoxaluria type I.
Neal M Rao, Anil Yallapragada, Kellen D Winden, Jeffrey Saver, David S Liebeskind

J Neuroimaging· April 2015

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A systems level, functional genomics analysis of chronic epilepsy.
Kellen D Winden, Stanislav L Karsten, Anatol Bragin, Lili C Kudo, Lauren Gehman

PLoS One· November 2011

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Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
Sarah A Sagi, Christian B Lessard, Kellen D Winden, Hiroko Maruyama, Jeremy C Koo

J Biol Chem· November 2011

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Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Ezra Y Rosen, Eric M Wexler, Revital Versano, Giovanni Coppola, Fuying Gao, Kellen D Winden

Neuron· September 2011

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Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.
Olga Peñagarikano, Brett S Abrahams, Edward I Herman, Kellen D Winden, Amos Gdalyahu

Cell· September 2011

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The organization of the transcriptional network in specific neuronal classes.
Kellen D Winden, Michael C Oldham, Karoly Mirnics, Philip J Ebert, Christo H Swan

Mol Syst Biol· October 2009

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