Publications by authors named "Christian Freise"

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Fibroblast growth factor-23 remodels vascular extracellular matrix via glycosaminoglycan induction: implications for calcification in chronic kidney disease.
Christian Freise, Tia Jernej, Susanne Metzkow, Jörg Schnorr, Matthias Taupitz

Ren Fail· December 2025

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Magnetic particle spectroscopy for Eu-VSOP quantification in intestinal inflammation: distinguishing nanoparticle signals from dietary contamination.
Norbert Löwa, Laura Golusda, Daniela Paclik, Heike Traub, Mathias Schannor, Christian Freise

Nanoscale Adv· October 2025

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The Uremic Toxins Inorganic Phosphate, Indoxylsulphate, p-Cresylsulphate, and TMAO Induce the Generation of Sulphated Glycosaminoglycans in Aortic Tissue and Vascular Cells via pAKT Signaling: A Missing Link in the "Gut-Matrix Axis".
Christian Freise, Susanne Metzkow, Andreas Zappe, Monika Ebert, Nicola Stolzenburg

Toxins (Basel)· April 2025

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Repeated Injection of Very Small Superparamagnetic Iron Oxide Particles (VSOPs) in Murine Atherosclerosis: A Safety Study.
Tobias Haase, Antje Ludwig, Anke Stach, Azadeh Mohtashamdolatshahi, Ralf Hauptmann, Christian Freise

Nanomaterials (Basel)· April 2024

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Inorganic Phosphate-Induced Extracellular Vesicles from Vascular Smooth Muscle Cells Contain Elevated Levels of Hyaluronic Acid, Which Enhance Their Interaction with Very Small Superparamagnetic Iron Oxide Particles.
Christian Freise, Karina Biskup, Véronique Blanchard, Jörg Schnorr, Matthias Taupitz

Int J Mol Sci· February 2024

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Uremic Toxin-Induced Exosome-like Extracellular Vesicles Contain Enhanced Levels of Sulfated Glycosaminoglycans which Facilitate the Interaction with Very Small Superparamagnetic Iron Oxide Particles.
Christian Freise, Andreas Zappe, Norbert Löwa, Jörg Schnorr, Kevin Pagel

Int J Mol Sci· September 2023

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Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles.
Laura Golusda, Anja A Kühl, Malte Lehmann, Katja Dahlke, Susanne Mueller, Christian Freise

Front Physiol· July 2022

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Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells.
Christian Freise, Hyunho Lee, Christopher Chronowski, Doug Chan, Jessica Cziomer

PLoS One· December 2021

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Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression.
Christian Freise, Uwe Querfeld, Antje Ludwig, Bernd Hamm, Jörg Schnorr

J Cell Mol Med· June 2021

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Non-contact monitoring of agitation and use of a sheltering device in patients with dementia in emergency departments: a feasibility study.
Lisa Kroll, Nikolaus Böhning, Heidi Müßigbrodt, Maria Stahl, Pavel Halkin, Christian Freise

BMC Psychiatry· April 2020

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Arterial tissue transcriptional profiles associate with tissue remodeling and cardiovascular phenotype in children with end-stage kidney disease.
Christian Freise, Betti Schaefer, Maria Bartosova, Aysun Bayazit, Ulrike Bauer

Sci Rep· July 2019

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Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis.
Hans-Ulrich Prommer, Johannes Maurer, Karoline von Websky, Christian Freise, Kerstin Sommer

Sci Rep· March 2018

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Collagen XIV and a related recombinant fragment protect human vascular smooth muscle cells from calcium-/phosphate-induced osteochondrocytic transdifferentiation.
Christian Freise, Veronika Bobb, Uwe Querfeld

Exp Cell Res· September 2017

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Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease.
Dorothea Burkhardt, Maria Bartosova, Betti Schaefer, Niels Grabe, Bernd Lahrmann, Christian Freise

PLoS One· June 2017

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Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases.
Christian Freise, Nadja Kretzschmar, Uwe Querfeld

BMC Cardiovasc Disord· September 2016

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The matrix metalloproteinases 2 and 9 initiate uraemic vascular calcifications.
Eva Hecht, Christian Freise, Karoline V Websky, Hamoud Nasser, Nadja Kretzschmar

Nephrol Dial Transplant· May 2016

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A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB.
Christian Freise, Ki Young Kim, Uwe Querfeld

Evid Based Complement Alternat Med· August 2015

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K⁺-channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells.
Christian Freise, Silke Heldwein, Ulrike Erben, Joachim Hoyer, Ralf Köhler

Liver Int· April 2015

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Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34.
Christian Freise, Uwe Querfeld

Pharmacol Res· July 2014

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Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.
Rolf Reiter, Christian Freise, Korinna Jöhrens, Carsten Kamphues, Daniel Seehofer

J Biomech· May 2014

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The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB.
Christian Freise, Martin Ruehl, Daniel Seehofer, Joachim Hoyer, Rajan Somasundaram

Invest New Drugs· April 2013

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(+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS.
Christian Freise, Wolfram Trowitzsch-Kienast, Ulrike Erben, Daniel Seehofer, Ki Young Kim

J Nutr Biochem· March 2013

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(+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9.
Christian Freise, Wolfram Trowitzsch-Kienast, Martin Ruehl, Ulrike Erben, Daniel Seehofer

Invest New Drugs· December 2012

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Absolute configuration of antifibrotic (+)-episesamin isolated from Lindera obtusiloba BLUME.
Wolfram Trowitzsch-Kienast, Martin Rühl, Ki Y Kim, Franziska Emmerling, Ulrike Erbenb, Christian Freise

Z Naturforsch C J Biosci· January 2012

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A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.
Christian Freise, Martin Ruehl, Ulrike Erben, Ulf Neumann, Daniel Seehofer

BMC Complement Altern Med· May 2011

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