Publications by authors named "Doug Chan"

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Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer.
Nicholas J Neill, Shankha Satpathy, Karsten Krug, Jitendra K Meena, Nivetha Ramesh Babu, Doug W Chan

Cancer Discov· November 2025

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Correction: RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
Derek Dustin, Guowei Gu, Amanda R Beyer, Sarah K Herzog, David G Edwards, Doug W Chan

Br J Cancer· October 2025

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Death-associated protein kinase 3 modulates migration and invasion of triple-negative breast cancer cells.
Junkai Wang, Anh M Tran-Huynh, Beom-Jun Kim, Doug W Chan, Matthew V Holt

PNAS Nexus· September 2024

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Kinase inhibitor pulldown assay (KiP) for clinical proteomics.
Alexander B Saltzman, Doug W Chan, Matthew V Holt, Junkai Wang, Eric J Jaehnig

Clin Proteomics· January 2024

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Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors.
Xiangdong Lv, Xuan Lu, Jin Cao, Qin Luo, Yao Ding, Doug W Chan, Eric C Chang

Science· September 2023

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Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair.
Chen Wang, Doug W Chan, Eric A Hendrickson

DNA Repair (Amst)· February 2023

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Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer.
Jing Zhang, Doug W Chan, Shiaw-Yih Lin

Biomedicines· November 2022

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Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells.
Christian Freise, Hyunho Lee, Christopher Chronowski, Doug Chan, Jessica Cziomer

PLoS One· December 2021

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Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss.
Christopher Chronowski, Viktor Akhanov, Doug Chan, Andre Catic, Milton Finegold

Metabolites· June 2021

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RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
Derek Dustin, Guowei Gu, Amanda R Beyer, Sarah K Herzog, David G Edwards, Doug W Chan

Br J Cancer· January 2021

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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.
Ze-Yi Zheng, Meenakshi Anurag, Jonathan T Lei, Jin Cao, Purba Singh, Doug W Chan, Eric C Chang

Cancer Cell· March 2020

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Microscaled proteogenomic methods for precision oncology.
Shankha Satpathy, Eric J Jaehnig, Karsten Krug, Beom-Jun Kim, Alexander B Saltzman, Doug W Chan

Nat Commun· January 2020

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DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
Ryoichi Matsunuma, Doug W Chan, Beom-Jun Kim, Purba Singh, Airi Han

Proc Natl Acad Sci U S A· December 2018

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gpGrouper: A Peptide Grouping Algorithm for Gene-Centric Inference and Quantitation of Bottom-Up Proteomics Data.
Alexander B Saltzman, Mei Leng, Bhoomi Bhatt, Purba Singh, Doug W Chan, Hamssika Chandrasekaran

Mol Cell Proteomics· November 2018

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Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer.
Jonathan T Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W Chan, Chanpheng Phommaly

Cell Rep· August 2018

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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.
Amritha Nair, Hsiang-Ching Chung, Tingting Sun, Siddhartha Tyagi, Lacey E Dobrolecki, Doug W Chan

Nat Med· May 2018

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The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.
Beom-Jun Kim, Doug W Chan, Sung Yun Jung, Yue Chen, Jun Qin

Cell Rep· May 2017

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The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.
Sang Jun Han, Khurshida Begum, Charles E Foulds, Ross A Hamilton, Suzanna Bailey, Doug Chan

Mol Pharmacol· January 2016

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Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics.
Charles E Foulds, Qin Feng, Chen Ding, Suzanna Bailey, Tamra L Hunsaker, Doug Chan

Mol Cell· July 2013

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Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements.
Chen Ding, Doug W Chan, Wanlin Liu, Mingwei Liu, Dong Li

Proc Natl Acad Sci U S A· April 2013

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Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Jing Li, Mingyue Chu, Shanshan Wang, Doug Chan, Shankang Qi

J Biol Chem· March 2012

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A data set of human endogenous protein ubiquitination sites.
Yi Shi, Doug W Chan, Sung Yun Jung, Anna Malovannaya, Yi Wang

Mol Cell Proteomics· May 2011

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Analysis of the human endogenous coregulator complexome.
Anna Malovannaya, Rainer B Lanz, Sung Yun Jung, Yaroslava Bulynko, Nguyen T Le, Doug W Chan

Cell· May 2011

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Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.
Jessica McCready, Jessica D Sims, Doug Chan, Daniel G Jay

BMC Cancer· June 2010

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Unbiased proteomic screen for binding proteins to modified lysines on histone H3.
Doug W Chan, Yi Wang, Meng Wu, Jiemin Wong, Jun Qin

Proteomics· May 2009

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