Publications by authors named "Christian Freund"

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Cut or bind? Antigen-specific processing mechanisms define CD4 T cell immunodominant epitopes for SARS-CoV-2 S and N proteins.
Miguel Álvaro-Benito, Esam T Abualrous, Holger Lingel, Stefan Meltendorf, Jakob Holzapfel, Christian Freund

Genome Med· November 2025

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Generation of patient-derived and gene-corrected hiPSC lines from Hereditary Hemorrhagic Telangiectasia type 2 patients with ACVRL1 c.1042delG mutation.
Kendy E Urdaneta, Francijna E van den Hil, Marga J Bouma, Herak Manjikian, Christine L Mummery, Christian M A H Freund

Stem Cell Res· October 2025

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Three-dimensional tissue engineered skeletal muscle modelling facioscapulohumeral muscular dystrophy.
Marnix Franken, Erik van der Wal, Dongxu Zheng, Bianca den Hamer, Patrick J van der Vliet, Christian Freund

Brain· May 2025

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SLAMF7 (CD319) on activated CD8 T cells transduces environmental cues to initiate cytotoxic effector cell responses.
Holger Lingel, Laura Fischer, Sven Remstedt, Benno Kuropka, Lars Philipsen, Christian Freund

Cell Death Differ· March 2025

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A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling.
Thomas A Bos, Elizaveta Polyakova, Janine Maria van Gils, Antoine A F de Vries, Marie-José Goumans, Christian Freund

Elife· March 2025

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Antigen presentation by MHC-II is shaped by competitive and cooperative allosteric mechanisms of peptide exchange.
Matthias Günther, Jana Sticht, Christian Freund, Thomas Höfer

Structure· February 2025

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Generation and genetic repair of two human induced pluripotent stem cell lines from patients with Epidermolysis Bullosa simplex associated with a heterozygous mutation in the translation initiation codon of KLHL24.
Spyridon T Pachis, Veronika Ramovs, Christian Freund, Cristina Has, Karine Raymond

Stem Cell Res· December 2024

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Generation of XPA p.Arg228T mutant LUMCi004-A cell line for modeling Xeroderma pigmentosum group A.
Halida P Widyastuti, Babet van der Vaart, Spyridon T Pachis, Christian Freund, Xavier Gidrol

Stem Cell Res· December 2024

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The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality.
Ghazaleh Hajmousa, Rodrigo Coutinho de Almeida, Niek Bloks, Alejandro Rodríguez Ruiz, Marga Bouma, Christian Freund

Clin Epigenetics· October 2024

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Validating human induced pluripotent stem cell-specific quality control tests for the release of an intermediate drug product in a Good Manufacturing Practice quality system.
Juan Novoa, Inge Westra, Esther Steeneveld, Natascha Fonseca Neves, Lizanne Daleman, Christian Freund

Cytotherapy· September 2024

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The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.
Miriam Bertazzon, Almudena Hurtado-Pico, Carlos Plaza-Sirvent, Marc Schuster, Marco Preußner, Christian Freund

Front Immunol· September 2024

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When less is more - a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping.
Alexander Stockhammer, Carissa Spalt, Antonia Klemt, Laila S Benz, Shelly Harel, Christian Freund

J Cell Sci· August 2024

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Reduced Protein Stability of 11 Pathogenic Missense STXBP1/MUNC18-1 Variants and Improved Disease Prediction.
Timon André, Annemiek A van Berkel, Gurdeep Singh, Esam T Abualrous, Gaurav D Diwan, Christian Freund

Biol Psychiatry· July 2024

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Lipid switches in the immunological synapse.
Gillian Griffiths, Britta Brügger, Christian Freund

J Biol Chem· July 2024

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Good Manufacturing Practice-compliant human induced pluripotent stem cells: from bench to putative clinical products.
Juan J Novoa, Inge M Westra, Esther Steeneveld, Natascha Fonseca Neves, Christiaan H Arendzen, Christian Freund

Cytotherapy· June 2024

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The population context is a driver of the heterogeneous response of epithelial cells to interferons.
Camila Metz-Zumaran, Zina M Uckeley, Patricio Doldan, Francesco Muraca, Yagmur Keser, Christian Freund

Mol Syst Biol· March 2024

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The α integrin cytoplasmic tail interacts with phosphoinositides and interferes with Akt activation.
Josephine Labus, Kerstin Tang, Petra Henklein, Ulrike Krüger, Andreas Hofmann, Christian Freund

Biochim Biophys Acta Biomembr· February 2024

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Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids.
Cosima Zimmermann, Gabrielle M Watson, Liane Bauersfeld, Richard Berry, Barbara Ciblis, Christian Freund

Proc Natl Acad Sci U S A· February 2024

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Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space.
Fabio Lolicato, Julia P Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Christian Freund

Elife· January 2024

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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Esam T Abualrous, Sebastian Stolzenberg, Jana Sticht, Marek Wieczorek, Yvette Roske, Christian Freund

Nat Chem Biol· October 2023

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CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids.
Thilo M Buck, Peter M J Quinn, Lucie P Pellissier, Aat A Mulder, Aldo Jongejan, Christian Freund

Stem Cell Reports· September 2023

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Genetic repair of a human induced pluripotent cell line from patient with Dutch-type cerebral amyloid angiopathy.
Dennis M Nahon, Sravya Ganesh, Francijna E van den Hil, Christian Freund, Christine L Mummery

Stem Cell Res· September 2023

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Isotopic Tracing of Nucleotide Sugar Metabolism in Human Pluripotent Stem Cells.
Federica Conte, Marek J Noga, Monique van Scherpenzeel, Raisa Veizaj, Rik Scharn, Christian Freund

Cells· July 2023

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AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype.
Nanda Boon, Xuefei Lu, Charlotte A Andriessen, Ioannis Moustakas, Thilo M Buck, Christian Freund

Stem Cell Reports· June 2023

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Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay.
Arend W Overeem, Yolanda W Chang, Ioannis Moustakas, Celine M Roelse, Sanne Hillenius, Christian Freund

Cell Rep Methods· June 2023

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