Publications by authors named "Christian Lobsiger"

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Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.
Irene Mei, Susanne Nichterwitz, Melanie Leboeuf, Jik Nijssen, Isadora Lenoel, Christian S Lobsiger

Genome Res· September 2025

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ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.
Isadora Lenoel, Matthieu Ribon, Félicie Lorenc, Aurélien Diebold, Clementine E Philibert, Christian S Lobsiger

Nat Commun· August 2025

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MAPT mutations in amyotrophic lateral sclerosis: clinical, neuropathological and functional insights.
Sibylle De Bertier, Géraldine Lautrette, Maria-Del-Mar Amador, Tomoko Miki, Séverine Boillée, Christian Stefan Lobsiger

J Neurol· March 2025

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Effect of ultrasound-mediated blood-spinal cord barrier opening on survival and motor function in females in an amyotrophic lateral sclerosis mouse model.
Anne-Sophie Montero, Ilyes Aliouat, Matthieu Ribon, Michael Canney, Lauriane Goldwirt, Christian S Lobsiger

EBioMedicine· August 2024

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A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
David Brenner, Kirsten Sieverding, Jahnavi Srinidhi, Susanne Zellner, Christopher Secker, Christian S Lobsiger

J Exp Med· May 2024

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The contribution of the peripheral immune system to neurodegeneration.
Félix Berriat, Christian S Lobsiger, Séverine Boillée

Nat Neurosci· June 2023

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Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity.
Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d'Incamps, Stéphanie Bigou, Christian S Lobsiger

Cell Mol Life Sci· May 2023

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Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement?
Susana Boluda, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Christian Lobsiger

Free Neuropathol· January 2023

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The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
Elisa Teyssou, Laura Chartier, Delphine Roussel, Nirma D Perera, Ivan Nemazanyy, Christian S Lobsiger

Int J Mol Sci· May 2022

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Impact of a frequent nearsplice variant in amyotrophic lateral sclerosis: optimising genetic screening for gene therapy opportunities.
François Muratet, Elisa Teyssou, Aude Chiot, Séverine Boillée, Christian S Lobsiger

J Neurol Neurosurg Psychiatry· September 2021

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Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1 ALS mice.
Matthieu Ribon, Céline Leone, Aude Chiot, Félix Berriat, Martine Rampanana, Christian S Lobsiger

Neurobiol Aging· May 2021

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Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43 transgenic mice.
Kirsten Sieverding, Johannes Ulmer, Clara Bruno, Takashi Satoh, William Tsao, Christian S Lobsiger

Exp Neurol· January 2021

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Imaging resident and recruited macrophage contribution to Wallerian degeneration.
Alexandre Boissonnas, Floriane Louboutin, Marie Laviron, Pierre-Louis Loyher, Elodie Reboussin, Christian S Lobsiger

J Exp Med· November 2020

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Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Aude Chiot, Sakina Zaïdi, Charlène Iltis, Matthieu Ribon, Félix Berriat, Christian S Lobsiger

Nat Neurosci· November 2020

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Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.
Clara Bruno, Kirsten Sieverding, Axel Freischmidt, Takashi Satoh, Paul Walther, Christian S Lobsiger

Brain Commun· August 2020

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New insights on the disease contribution of neuroinflammation in amyotrophic lateral sclerosis.
Aude Chiot, Christian S Lobsiger, Séverine Boillée

Curr Opin Neurol· October 2019

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Ultrasound-Induced Blood-Spinal Cord Barrier Opening in Rabbits.
Anne-Sophie Montero, Franck Bielle, Lauriane Goldwirt, Adrien Lalot, Guillaume Bouchoux, Christian Lobsiger

Ultrasound Med Biol· September 2019

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Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10 mouse.
Emmanuelle C Genin, Blandine Madji Hounoum, Sylvie Bannwarth, Konstantina Fragaki, Sandra Lacas-Gervais, Christian S Lobsiger

Acta Neuropathol· July 2019

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Heterozygous loss has opposing effects in early and late stages of ALS in mice.
David Brenner, Kirsten Sieverding, Clara Bruno, Patrick Lüningschrör, Eva Buck, Christian S Lobsiger

J Exp Med· February 2019

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Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease.
Anne-Laure Bulteau, Natalia P Mena, Françoise Auchère, Irene Lee, Annick Prigent, Christian S Lobsiger

Free Radic Biol Med· July 2017

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Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes.
Vincent R Parillaud, Guillaume Lornet, Yann Monnet, Anne-Laure Privat, Andrei T Haddad, Christian S Lobsiger

J Neuroinflammation· March 2017

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System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice.
Pinar Mesci, Sakina Zaïdi, Christian S Lobsiger, Stéphanie Millecamps, Carole Escartin

Brain· January 2015

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Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice.
Christian S Lobsiger, Don W Cleveland

Proc Natl Acad Sci U S A· January 2014

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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.
Christian S Lobsiger, Severine Boillée, Christine Pozniak, Amir M Khan, Melissa McAlonis-Downes

Proc Natl Acad Sci U S A· November 2013

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Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.
Christine Vande Velde, Karli K McDonald, Yasmin Boukhedimi, Melissa McAlonis-Downes, Christian S Lobsiger

PLoS One· November 2011

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