Publications by authors named "Christopher Secker"

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Investigating Endogenous Opioids Unravels the Mechanisms Behind Opioid-Induced Constipation, a Mathematical Modeling Approach.
Celvic Coomber, Surahit Chewle, Christopher Secker, Konstantin Fackeldey, Marcus Weber

Int J Mol Sci· June 2025

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A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
David Brenner, Kirsten Sieverding, Jahnavi Srinidhi, Susanne Zellner, Christopher Secker

J Exp Med· May 2024

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AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Philipp Trepte, Christopher Secker, Julien Olivet, Jeremy Blavier, Simona Kostova

Mol Syst Biol· April 2024

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Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Matthew G Alteen, Justin C Deme, Claudia P Alvarez, Peter Loppnau, Ashley Hutchinson, Christopher Secker

Structure· September 2023

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Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists.
Christopher Secker, Konstantin Fackeldey, Marcus Weber, Sourav Ray, Christoph Gorgulla

J Cheminform· September 2023

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The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Christopher Secker, Angelika Y Motzny, Simona Kostova, Alexander Buntru, Lucas Helmecke

J Neurochem· July 2023

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AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B Maseko, Soon Gang Choi

bioRxiv· June 2023

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Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.
Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu

Cell Syst· April 2022

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CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins.
Christopher Secker, Simona Kostova, Hannah Niederlechner, Stephanie Beetz, Ina Wendland

J Mol Biol· December 2021

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M Pentimalli, René Jüttner, Christopher Secker

Nat Commun· March 2021

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N-methyl-D-aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit.
Nina Kerstin Wenke, Jakob Kreye, Ewa Andrzejak, Adriana van Casteren, Jonas Leubner, Christopher Secker

Ann Neurol· May 2019

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LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Christopher Secker

Mol Syst Biol· July 2018

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DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.
Philipp Trepte, Alexander Buntru, Konrad Klockmeier, Lindsay Willmore, Anup Arumughan, Christopher Secker

J Mol Biol· October 2015

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