Publications by authors named "Christian Stegmann"

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Transcriptional profile of the rat cardiovascular system at single-cell resolution.
Alessandro Arduini, Stephen J Fleming, Ling Xiao, Amelia W Hall, Amer-Denis Akkad, Christian M Stegmann

Cell Rep· January 2025

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Transcriptional profile of the rat cardiovascular system at single cell resolution.
Alessandro Arduini, Stephen J Fleming, Ling Xiao, Amelia W Hall, Amer-Denis Akkad, Christian M Stegmann

bioRxiv· November 2023

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FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.
Frank Stephan, Matthias Gross, Anna Grebinyk, Zakaria Aboulbanine, Zohrab Amirkhanyan, Christian Stegmann

Phys Med· December 2022

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Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.
Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C Hill, Christian M Stegmann

Nature· August 2022

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MACA: marker-based automatic cell-type annotation for single-cell expression data.
Yang Xu, Simon J Baumgart, Christian M Stegmann, Sikander Hayat

Bioinformatics· March 2022

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Deep learning enables genetic analysis of the human thoracic aorta.
James P Pirruccello, Mark D Chaffin, Elizabeth L Chou, Stephen J Fleming, Honghuang Lin, Christian M Stegmann

Nat Genet· January 2022

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Transcriptional and Cellular Diversity of the Human Heart.
Nathan R Tucker, Mark Chaffin, Stephen J Fleming, Amelia W Hall, Victoria A Parsons, Christian M Stegmann

Circulation· August 2020

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Myocyte-Specific Upregulation of in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis.
Nathan R Tucker, Mark Chaffin, Kenneth C Bedi, Irinna Papangeli, Amer-Denis Akkad, Christian M Stegmann

Circulation· August 2020

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Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis.
Nathan R Tucker, Mark Chaffin, Kenneth C Bedi, Irinna Papangeli, Amer-Denis Akkad, Christian M Stegmann

medRxiv· April 2020

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Roman C Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, André Hilpmann, Christian M Stegmann

Proc Natl Acad Sci U S A· February 2019

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Binding kinetics in drug discovery - A current perspective.
Victoria Georgi, Dorothee Andres, Amaury E Fernandez-Montalvan, Christian M Stegmann, Andreas Becker

Front Biosci (Landmark Ed)· January 2017

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Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9.
Pelin Ayaz, Dorothee Andres, Dennis A Kwiatkowski, Carl-Christian Kolbe, Philip Lienau, Christian M Stegmann

ACS Chem Biol· June 2016

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Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.
Florian Prinz, Vera Puetter, Simon J Holton, Dorothee Andres, Christian M Stegmann

J Biol Chem· May 2016

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Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Renato Ferreira de Freitas, Mohammad S Eram, Magdalena M Szewczyk, Holger Steuber, David Smil, Christian M Stegmann

J Med Chem· February 2016

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An autoinhibited state in the structure of Thermotoga maritima NusG.
Johanna Drögemüller, Christian M Stegmann, Angshuman Mandal, Thomas Steiner, Björn M Burmann

Structure· March 2013

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Ligand-optimized electroless synthesis of silver nanotubes and their activity in the reduction of 4-nitrophenol.
Falk Muench, Markus Rauber, Christian Stegmann, Stefan Lauterbach, Ulrike Kunz

Nanotechnology· October 2011

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Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis.
Pawel Burkhardt, Christian M Stegmann, Benjamin Cooper, Tobias H Kloepper, Cordelia Imig

Proc Natl Acad Sci U S A· September 2011

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The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein.
Christian M Stegmann, Reinhard Lührmann, Markus C Wahl

PLoS One· April 2010

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The thermodynamic influence of trapped water molecules on a protein-ligand interaction.
Christian M Stegmann, Daniel Seeliger, George M Sheldrick, Bert L de Groot, Markus C Wahl

Angew Chem Int Ed Engl· September 2009

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Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Rongsheng Jin, Stefan Sikorra, Christian M Stegmann, Andreas Pich, Thomas Binz

Biochemistry· September 2007

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Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C Burnett, Gordon Ruthel, Christian M Stegmann, Rekha G Panchal, Tam L Nguyen

J Biol Chem· February 2007

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