Publications by authors named "Christopher A Cottrell"

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mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model.
Nelson R Wu, Nathan Beutler, Xiaozhen Hu, Patrick D Skog, Alessia Liguori, Christopher A Cottrell

NPJ Vaccines· November 2025

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Antibody feedback establishes an affinity brake in the germinal center.
Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel L V Bader, Ryan H Lim, Christopher A Cottrell

bioRxiv· November 2025

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Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
Zhenfei Xie, Xuesong Wang, Yu Yan, Jon M Steichen, Krystal M Ma, Christopher A Cottrell

Sci Immunol· October 2025

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Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial.
Xiaohe Lin, Christopher A Cottrell, Oleksandr Kalyuzhniy, Ryan Tingle, Michael Kubitz

Proc Natl Acad Sci U S A· August 2025

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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Payal P Pratap, Christopher A Cottrell, James Quinn, Diane G Carnathan, Daniel L V Bader

NPJ Vaccines· August 2025

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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Krystal M Ma, Henry J Sutton, Payal P Pratap, Jon M Steichen, Diane Carnathan, Christopher A Cottrell

Sci Immunol· August 2025

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Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.
Jordan R Willis, Madhu Prabhakaran, Michelle Muthui, Ansuya Naidoo, Troy Sincomb, Christopher A Cottrell

Science· July 2025

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Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.
Parham Ramezani-Rad, Christopher A Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais

Sci Transl Med· July 2025

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Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
K Rachael Parks, Zoe Moodie, Mary A Allen, Catherine Yen, Briana D Furch, Christopher A Cottrell

Sci Transl Med· July 2025

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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Payal P Pratap, Christopher A Cottrell, James Quinn, Diane G Carnathan, Daniel L V Bader

bioRxiv· June 2025

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Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial.
Xiaohe Lin, Christopher A Cottrell, Oleksandr Kalyuzhniy, Ryan Tingle, Michael Kubitz

bioRxiv· May 2025

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The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman primates.
Parham Ramezani-Rad, Ester Marina-Zárate, Laura Maiorino, Amber Myers, Katarzyna Kaczmarek Michaels, Christopher A Cottrell

J Clin Invest· April 2025

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Antigen avidity drives the durability of the vaccine immune response.
Nicole G Weidner, Mauricio V Padilla, Layne Pruitt, Christopher A Cottrell, Kristyn Gonzales

bioRxiv· April 2025

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DNA origami vaccines program antigen-focused germinal centers.
Anna Romanov, Grant A Knappe, Larance Ronsard, Heikyung Suh, Marjan Omer, Christopher A Cottrell

bioRxiv· March 2025

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Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models.
Parham Ramezani-Rad, Christopher A Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais

bioRxiv· January 2025

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Dose-dependent regulation of immune memory responses against HIV by saponin monophosphoryl lipid A nanoparticle adjuvant.
Parham Ramezani-Rad, Ester Marina-Zárate, Laura Maiorino, Amber Myers, Katarzyna Kaczmarek Michaels, Christopher A Cottrell

bioRxiv· August 2024

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Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Torben Schiffner, Ivy Phung, Rashmi Ray, Adriana Irimia, Ming Tian, Christopher A Cottrell

Nat Immunol· July 2024

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Priming antibody responses to the fusion peptide in rhesus macaques.
Christopher A Cottrell, Payal P Pratap, Kimberly M Cirelli, Diane G Carnathan, Chiamaka A Enemuo

NPJ Vaccines· July 2024

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Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Torben Schiffner, Ivy Phung, Rashmi Ray, Adriana Irimia, Ming Tian, Christopher A Cottrell

Nat Immunol· June 2024

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Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates.
Jon M Steichen, Ivy Phung, Eugenia Salcedo, Gabriel Ozorowski, Jordan R Willis, Christopher A Cottrell

Science· May 2024

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Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice.
Christopher A Cottrell, Xiaozhen Hu, Jeong Hyun Lee, Patrick Skog, Sai Luo

Sci Transl Med· May 2024

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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.
Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann

Sci Immunol· May 2024

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Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate.
Vaneet K Sharma, Sergey Menis, Evan T Brower, Eddy Sayeed, Jim Ackland, Christopher A Cottrell

Pharmaceutics· May 2024

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Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.
Allan C deCamp, Martin M Corcoran, William J Fulp, Jordan R Willis, Christopher A Cottrell

NPJ Vaccines· March 2024

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High frequency of HIV precursor-target-specific B cells in sub-Saharan populations.
Flavio Matassoli, Alberto Cagigi, Chen-Hsiang Shen, Amy R Henry, Timothy S Johnston, Christopher A Cottrell

Cell Rep· December 2023

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