Publications by authors named "Gabriel Ozorowski"

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Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody-viral glycoprotein complexes.
Leigh M Sewall, Rebeca de Paiva Froes Rocha, Grace Gibson, Michelle Louie, Zhenfei Xie, Gabriel Ozorowski

Nat Biomed Eng· November 2025

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HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.
Emma I M M Reiss, Karlijn van der Straten, Laura T M Graus, Marloes Grobben, Kilian E Vlaming, Gabriel Ozorowski

Nat Commun· November 2025

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Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
Zhenfei Xie, Xuesong Wang, Yu Yan, Jon M Steichen, Krystal M Ma, Gabriel Ozorowski

Sci Immunol· October 2025

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Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery.
Xuduo Li, Ipsita Krishnamurthy, Nitesh Mishra, Nicole E James, Rohan Roy Chowdhury, Gabriel Ozorowski

bioRxiv· October 2025

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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
Nitesh Mishra, Bo Liang, Ryan S Roark, Amrit Ghosh, Sean Callaghan, Gabriel Ozorowski

bioRxiv· October 2025

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Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation.
Mateusz Kędzior, Swastik Phulera, Monica L Fernández-Quintero, Johannes R Loeffler, Collin Joyce, Gabriel Ozorowski

bioRxiv· October 2025

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A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers.
Devidas N Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Gabriel Ozorowski

J Virol· September 2025

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GMP Manufacturing and Characterization of the HIV Booster Immunogen HxB2.WT.Core-C4b for Germline Targeting Vaccine Strategies.
Sammaiah Pallerla, Latha Kallur Siddaramaiah, Philipp Mundsperger, Dietmar Katinger, Katharina Fauland, Gabriel Ozorowski

Vaccines (Basel)· September 2025

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HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs.
Javier Guenaga, Monika Adori, Shridhar Bale, Swastik Phulera, Ioannis Zygouras, Gabriel Ozorowski

bioRxiv· September 2025

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Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.
Shridhar Bale, Elena Gustchina, Javier Guenaga, Victor Ayala, Wen-Hsin Lee, Gabriel Ozorowski

NPJ Vaccines· August 2025

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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Payal P Pratap, Christopher A Cottrell, James Quinn, Diane G Carnathan, Daniel L V Bader, Gabriel Ozorowski

NPJ Vaccines· August 2025

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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Krystal M Ma, Henry J Sutton, Payal P Pratap, Jon M Steichen, Diane Carnathan, Gabriel Ozorowski

Sci Immunol· August 2025

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CryoEM Structures of Antibodies Elicited by Germline-Targeting HIV MPER Epitope-Scaffolds.
Jiachen Huang, Olivia M Swanson, Kimmo Rantalainen, Monica L Fernández-Quintero, Johannes R Loeffler, Gabriel Ozorowski

bioRxiv· August 2025

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Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.
Jordan R Willis, Madhu Prabhakaran, Michelle Muthui, Ansuya Naidoo, Troy Sincomb, Gabriel Ozorowski

Science· July 2025

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Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Tom G Caniels, Madhu Prabhakaran, Gabriel Ozorowski, Kellie J MacPhee, Weiwei Wu

Science· July 2025

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Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.
Parham Ramezani-Rad, Christopher A Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais, Gabriel Ozorowski

Sci Transl Med· July 2025

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Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
K Rachael Parks, Zoe Moodie, Mary A Allen, Catherine Yen, Briana D Furch, Gabriel Ozorowski

Sci Transl Med· July 2025

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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer.
Fabian-Alexander Schleich, Shridhar Bale, Javier Guenaga, Gabriel Ozorowski, Monika Àdori

Immunity· June 2025

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Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response.
Kenta Matsuda, Mitra Harrison, Eleanor Wettstein, Jessica Pederson, Alyssa A Pullano, Gabriel Ozorowski

Nat Commun· June 2025

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Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion.
Kristen A Rodrigues, Yiming J Zhang, Jonathan Lam, Aereas Aung, Duncan M Morgan, Gabriel Ozorowski

Sci Transl Med· June 2025

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Replaying germinal center evolution on a quantified affinity landscape.
William S DeWitt, Ashni A Vora, Tatsuya Araki, Jared G Galloway, Tanwee Alkutkar, Gabriel Ozorowski

bioRxiv· June 2025

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Virus glycoprotein nanodisc platform for vaccine design.
Kimmo Rantalainen, Alessia Liguori, Gabriel Ozorowski, Claudia Flynn, Jon M Steichen

bioRxiv· June 2025

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Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques.
Yasmine A Issah, Xintao Hu, John Isaac, Xiaoying Shen, Dominique Davis, Gabriel Ozorowski

bioRxiv· May 2025

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Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope.
Michael V Bick, Eduard Puig, David Beauparlant, Rebecca Nedellec, Iszac Burton, Gabriel Ozorowski

Cell Rep· April 2025

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Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models.
Parham Ramezani-Rad, Christopher A Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais, Gabriel Ozorowski

bioRxiv· January 2025

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