Publications by authors named "Sean Callaghan"

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Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies.
Ryan S Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell, Sean Callaghan

J Exp Med· October 2025

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Directed evolution of a stem-helix-targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity.
Panpan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo, Ge Song, Sean Callaghan

bioRxiv· October 2025

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Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery.
Xuduo Li, Ipsita Krishnamurthy, Nitesh Mishra, Nicole E James, Rohan Roy Chowdhury, Sean Callaghan

bioRxiv· October 2025

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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
Nitesh Mishra, Bo Liang, Ryan S Roark, Amrit Ghosh, Sean Callaghan

bioRxiv· October 2025

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Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Ge Song, Meng Yuan, Hejun Liu, Tazio Capozzola, Ryan N Lin, Sean Callaghan

Cell Rep· July 2025

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Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.
Amrit Raj Ghosh, Rumi Habib, Nitesh Mishra, Ryan S Roark, Madhav Akauliya, Sean Callaghan

bioRxiv· June 2025

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Calculating age-specific prevalence rates of female genital mutilation / cutting (FGM/C) for use as an input variable in extrapolation calculations and as predictors of future prevalence in countries of origin.
Sean Callaghan

PLoS One· May 2025

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Decoding protein dynamicity in DNA ligase activity through deep learning-based structural ensembles.
Nitesh Mishra, Sean Callaghan, Bryan Briney

bioRxiv· November 2024

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Conformational ensemble-based framework enables rapid development of Lassa virus vaccine candidates.
Nitesh Mishra, Gabriel Avillion, Sean Callaghan, Charlotte DiBiase, Jonathan Hurtado

bioRxiv· November 2024

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HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene.
Ryan S Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell, Sean Callaghan

bioRxiv· June 2024

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Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Ge Song, Meng Yuan, Hejun Liu, Tazio Capozzola, Ryan N Lin, Sean Callaghan

bioRxiv· April 2023

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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Panpan Zhou, Ge Song, Hejun Liu, Meng Yuan, Wan-Ting He, Sean Callaghan

Immunity· March 2023

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Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus.
Fangzhu Zhao, Zachary T Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D Allen, Sean Callaghan

Nat Commun· September 2022

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Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Wan-Ting He, Meng Yuan, Sean Callaghan, Rami Musharrafieh, Ge Song

Sci Transl Med· August 2022

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Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
Wan-Ting He, Rami Musharrafieh, Ge Song, Katharina Dueker, Longping V Tse, Sean Callaghan

Nat Immunol· June 2022

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A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.
Panpan Zhou, Meng Yuan, Ge Song, Nathan Beutler, Namir Shaabani, Sean Callaghan

Sci Transl Med· March 2022

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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease.
Panpan Zhou, Ge Song, Wan-Ting He, Nathan Beutler, Longping V Tse, Sean Callaghan

bioRxiv· March 2022

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Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
Wan-Ting He, Rami Musharrafieh, Ge Song, Katharina Dueker, Longping V Tse, Sean Callaghan

bioRxiv· February 2022

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A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.
Panpan Zhou, Meng Yuan, Ge Song, Nathan Beutler, Namir Shaabani, Sean Callaghan

bioRxiv· January 2022

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A Rapid Assay for SARS-CoV-2 Neutralizing Antibodies That Is Insensitive to Antiretroviral Drugs.
Deli Huang, Jenny Tuyet Tran, Linghang Peng, Linlin Yang, Raymond T Suhandynata, Sean Callaghan

J Immunol· July 2021

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Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.
Joel D Allen, Himanshi Chawla, Firdaus Samsudin, Lorena Zuzic, Aishwary Tukaram Shivgan, Sean Callaghan

Biochemistry· July 2021

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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Hannah L Turner, Raiees Andrabi, Christopher A Cottrell, Sara T Richey, Ge Song, Sean Callaghan

Sci Adv· July 2021

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Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection.
Ge Song, Wan-Ting He, Sean Callaghan, Fabio Anzanello, Deli Huang

Nat Commun· May 2021

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Site-specific steric control of SARS-CoV-2 spike glycosylation.
Joel D Allen, Himanshi Chawla, Firdaus Samsudin, Lorena Zuzic, Aishwary Tukaram Shivgan, Sean Callaghan

bioRxiv· March 2021

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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Hannah L Turner, Raiees Andrabi, Christopher A Cottrell, Sara T Richey, Ge Song, Sean Callaghan

bioRxiv· February 2021

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